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The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.

Minai K, Ogawa T, Kawai M, Komukai K, Tanaka T, Ogawa K, Nagoshi T, Arase S, Morimoto S, Inoue Y, Sekiyama H, Urabe A, Matsuo S, Hongo K, Yoshimura M - PLoS ONE (2014)

Bottom Line: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001).The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males.Perhaps, the low reactivity of BNP is causally associated with IHD in males.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

ABSTRACT

Objective: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD.

Methods: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed.

Results: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001). The multiple regression analysis examining the logBNP values showed that age, a male gender, low left ventricular ejection fraction, low body mass index, serum creatinine, atrial fibrillation and IHD per se were significant explanatory variables. When the total study population was divided according to gender, the plasma BNP levels were found to be significantly lower in the IHD group than in the non-IHD group among males (p<0.001), but not females (p = NS). Furthermore, a multiple logistic regression analysis of IHD showed the logBNP value to be a significant explanatory variable in males (regression coefficient: -0.669, p<0.001), but not females (p = NS).

Conclusions: The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males. Perhaps, the low reactivity of BNP is causally associated with IHD in males. We hope that this study will serve as a test of future prospective studies.

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Related in: MedlinePlus

The Forest Plot displaying the odds ratio about risk of IHD in a females.BNP, B-type natriuretic peptide; LVEF, Left ventricular ejection fraction; BMI, Body mass index; AF, Atrial fibrillation; IHD, Ischemic heart disease; s-Cr, Serum creatinine.
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pone-0108983-g002: The Forest Plot displaying the odds ratio about risk of IHD in a females.BNP, B-type natriuretic peptide; LVEF, Left ventricular ejection fraction; BMI, Body mass index; AF, Atrial fibrillation; IHD, Ischemic heart disease; s-Cr, Serum creatinine.

Mentions: We finally examined the factors determining the presence of IHD; a multiple logistic regression analysis was performed for the determination of IHD by using the logBNP, LVEF, age, BMI, AF and s-Cr as explanatory variables in females and males. As shown in Tables 5 and Figure 2 (Females), and Table 6, and Figure 3 (Males), the trend between females and males was similar for age (significant in each gender), BMI (significant in each gender), AF (significant in each gender) and LVEF (not significant in each gender); however, the s-Cr was not significant in females (p = NS) but was significant in males (p<0.05). This result may suggest that chronic kidney disease is a more important risk factor for IHD in males than in females. It is noteworthy that the logBNP was not significantly associated with IHD in females (p = NS, actually p = 0.719), but was significantly and inversely associated with IHD in males (Regression coefficient: −0.669, p <0.001). Thus, the logBNP may only correlate with IHD in males, and may have a possible causative role, although it is difficult to distinguish between cause and effect based on the present analysis.


The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.

Minai K, Ogawa T, Kawai M, Komukai K, Tanaka T, Ogawa K, Nagoshi T, Arase S, Morimoto S, Inoue Y, Sekiyama H, Urabe A, Matsuo S, Hongo K, Yoshimura M - PLoS ONE (2014)

The Forest Plot displaying the odds ratio about risk of IHD in a females.BNP, B-type natriuretic peptide; LVEF, Left ventricular ejection fraction; BMI, Body mass index; AF, Atrial fibrillation; IHD, Ischemic heart disease; s-Cr, Serum creatinine.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215845&req=5

pone-0108983-g002: The Forest Plot displaying the odds ratio about risk of IHD in a females.BNP, B-type natriuretic peptide; LVEF, Left ventricular ejection fraction; BMI, Body mass index; AF, Atrial fibrillation; IHD, Ischemic heart disease; s-Cr, Serum creatinine.
Mentions: We finally examined the factors determining the presence of IHD; a multiple logistic regression analysis was performed for the determination of IHD by using the logBNP, LVEF, age, BMI, AF and s-Cr as explanatory variables in females and males. As shown in Tables 5 and Figure 2 (Females), and Table 6, and Figure 3 (Males), the trend between females and males was similar for age (significant in each gender), BMI (significant in each gender), AF (significant in each gender) and LVEF (not significant in each gender); however, the s-Cr was not significant in females (p = NS) but was significant in males (p<0.05). This result may suggest that chronic kidney disease is a more important risk factor for IHD in males than in females. It is noteworthy that the logBNP was not significantly associated with IHD in females (p = NS, actually p = 0.719), but was significantly and inversely associated with IHD in males (Regression coefficient: −0.669, p <0.001). Thus, the logBNP may only correlate with IHD in males, and may have a possible causative role, although it is difficult to distinguish between cause and effect based on the present analysis.

Bottom Line: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001).The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males.Perhaps, the low reactivity of BNP is causally associated with IHD in males.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

ABSTRACT

Objective: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD.

Methods: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed.

Results: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001). The multiple regression analysis examining the logBNP values showed that age, a male gender, low left ventricular ejection fraction, low body mass index, serum creatinine, atrial fibrillation and IHD per se were significant explanatory variables. When the total study population was divided according to gender, the plasma BNP levels were found to be significantly lower in the IHD group than in the non-IHD group among males (p<0.001), but not females (p = NS). Furthermore, a multiple logistic regression analysis of IHD showed the logBNP value to be a significant explanatory variable in males (regression coefficient: -0.669, p<0.001), but not females (p = NS).

Conclusions: The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males. Perhaps, the low reactivity of BNP is causally associated with IHD in males. We hope that this study will serve as a test of future prospective studies.

Show MeSH
Related in: MedlinePlus