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The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.

Minai K, Ogawa T, Kawai M, Komukai K, Tanaka T, Ogawa K, Nagoshi T, Arase S, Morimoto S, Inoue Y, Sekiyama H, Urabe A, Matsuo S, Hongo K, Yoshimura M - PLoS ONE (2014)

Bottom Line: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001).The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males.Perhaps, the low reactivity of BNP is causally associated with IHD in males.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

ABSTRACT

Objective: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD.

Methods: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed.

Results: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001). The multiple regression analysis examining the logBNP values showed that age, a male gender, low left ventricular ejection fraction, low body mass index, serum creatinine, atrial fibrillation and IHD per se were significant explanatory variables. When the total study population was divided according to gender, the plasma BNP levels were found to be significantly lower in the IHD group than in the non-IHD group among males (p<0.001), but not females (p = NS). Furthermore, a multiple logistic regression analysis of IHD showed the logBNP value to be a significant explanatory variable in males (regression coefficient: -0.669, p<0.001), but not females (p = NS).

Conclusions: The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males. Perhaps, the low reactivity of BNP is causally associated with IHD in males. We hope that this study will serve as a test of future prospective studies.

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Related in: MedlinePlus

Comparison of the logBNP levels between the non-IHD and IHD groups.A: In the overall population. B: In males and females. N: non-ischemic heart disease group (non-IHD); I: ischemic heart disease group (IHD). BNP: B-type natriuretic peptide.
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pone-0108983-g001: Comparison of the logBNP levels between the non-IHD and IHD groups.A: In the overall population. B: In males and females. N: non-ischemic heart disease group (non-IHD); I: ischemic heart disease group (IHD). BNP: B-type natriuretic peptide.

Mentions: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group as shown in Figure 1-A. In order to identify factors contributing to the difference in the plasma BNP levels between the IHD and non-IHD groups among the total study population, statistical analyses was performed, as shown in Table 3 and Table 4. Table 3 is the results of the simple regression analysis of the logBNP values using clinical factors as explanatory variables. Table 4 shows the results of the subsequent multiple regression analysis. Consequently, age, gender, BMI, s-Cr, LVEF, AF, and IHD were found to be significant determinants of the logBNP value. Among these factors, it is noteworthy that IHD per se was significantly and inversely correlated with the logBNP value.


The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.

Minai K, Ogawa T, Kawai M, Komukai K, Tanaka T, Ogawa K, Nagoshi T, Arase S, Morimoto S, Inoue Y, Sekiyama H, Urabe A, Matsuo S, Hongo K, Yoshimura M - PLoS ONE (2014)

Comparison of the logBNP levels between the non-IHD and IHD groups.A: In the overall population. B: In males and females. N: non-ischemic heart disease group (non-IHD); I: ischemic heart disease group (IHD). BNP: B-type natriuretic peptide.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215845&req=5

pone-0108983-g001: Comparison of the logBNP levels between the non-IHD and IHD groups.A: In the overall population. B: In males and females. N: non-ischemic heart disease group (non-IHD); I: ischemic heart disease group (IHD). BNP: B-type natriuretic peptide.
Mentions: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group as shown in Figure 1-A. In order to identify factors contributing to the difference in the plasma BNP levels between the IHD and non-IHD groups among the total study population, statistical analyses was performed, as shown in Table 3 and Table 4. Table 3 is the results of the simple regression analysis of the logBNP values using clinical factors as explanatory variables. Table 4 shows the results of the subsequent multiple regression analysis. Consequently, age, gender, BMI, s-Cr, LVEF, AF, and IHD were found to be significant determinants of the logBNP value. Among these factors, it is noteworthy that IHD per se was significantly and inversely correlated with the logBNP value.

Bottom Line: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001).The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males.Perhaps, the low reactivity of BNP is causally associated with IHD in males.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

ABSTRACT

Objective: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD.

Methods: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed.

Results: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p<0.001). The multiple regression analysis examining the logBNP values showed that age, a male gender, low left ventricular ejection fraction, low body mass index, serum creatinine, atrial fibrillation and IHD per se were significant explanatory variables. When the total study population was divided according to gender, the plasma BNP levels were found to be significantly lower in the IHD group than in the non-IHD group among males (p<0.001), but not females (p = NS). Furthermore, a multiple logistic regression analysis of IHD showed the logBNP value to be a significant explanatory variable in males (regression coefficient: -0.669, p<0.001), but not females (p = NS).

Conclusions: The plasma BNP levels were relatively low in stable patients with IHD compared with those observed in stable patients with non-IHD; this tendency was evident in males. Perhaps, the low reactivity of BNP is causally associated with IHD in males. We hope that this study will serve as a test of future prospective studies.

Show MeSH
Related in: MedlinePlus