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LIN28B promotes colon cancer migration and recurrence.

Pang M, Wu G, Hou X, Hou N, Liang L, Jia G, Shuai P, Luo B, Wang K, Li G - PLoS ONE (2014)

Bottom Line: LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members.LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence.In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.

ABSTRACT
LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members. In this study, we showed that LIN28B expression promotes migration and recurrence of colon cancer. Immunohistochemistry and reverse-transcription polymerase chain reactions were performed to detect LIN28B expression in colon cancer tissue microarrays, paraffin-embedded surgical resected tissues and cancer cells. Loss-of-function, migration and proliferation analyses were performed to delineate the potential roles of LIN28B in colon cancer. LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence. LIN28B suppression inhibited the migration of SW480 colon cancer cells and facilitated the cytotoxicity induced by oxaliplatin in SW480 and HCT116 colon cancer cells. In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.

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LIN28B overexpression correlated with reduced patient survival and an increased likelihood of tumour recurrence.(A) Higher LIN28B staining intensity from stage I, II and III colon cancers correlated with reduced patient survival. (B) High LIN28B expression was related to a higher probability of tumour recurrence (p<0.01; log rank test).
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pone-0109169-g002: LIN28B overexpression correlated with reduced patient survival and an increased likelihood of tumour recurrence.(A) Higher LIN28B staining intensity from stage I, II and III colon cancers correlated with reduced patient survival. (B) High LIN28B expression was related to a higher probability of tumour recurrence (p<0.01; log rank test).

Mentions: Data from patients who underwent surgery (TNM I-III, paraffin-embedded surgical resected tissues) were further analysed via log rank tests to investigate the influence of LIN28B overexpression on patient survival and recurrence. This analysis revealed a correlation between low-intensity LIN28B staining from samples of TNM grade I and II tumours and increased patient survival (Mantel-Cox p<0.01; Breslow, p<0.01) and a lower likelihood of tumour recurrence (Mantel-Cox p<0.01; Breslow p<0.01) (Fig. 2).


LIN28B promotes colon cancer migration and recurrence.

Pang M, Wu G, Hou X, Hou N, Liang L, Jia G, Shuai P, Luo B, Wang K, Li G - PLoS ONE (2014)

LIN28B overexpression correlated with reduced patient survival and an increased likelihood of tumour recurrence.(A) Higher LIN28B staining intensity from stage I, II and III colon cancers correlated with reduced patient survival. (B) High LIN28B expression was related to a higher probability of tumour recurrence (p<0.01; log rank test).
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4215835&req=5

pone-0109169-g002: LIN28B overexpression correlated with reduced patient survival and an increased likelihood of tumour recurrence.(A) Higher LIN28B staining intensity from stage I, II and III colon cancers correlated with reduced patient survival. (B) High LIN28B expression was related to a higher probability of tumour recurrence (p<0.01; log rank test).
Mentions: Data from patients who underwent surgery (TNM I-III, paraffin-embedded surgical resected tissues) were further analysed via log rank tests to investigate the influence of LIN28B overexpression on patient survival and recurrence. This analysis revealed a correlation between low-intensity LIN28B staining from samples of TNM grade I and II tumours and increased patient survival (Mantel-Cox p<0.01; Breslow, p<0.01) and a lower likelihood of tumour recurrence (Mantel-Cox p<0.01; Breslow p<0.01) (Fig. 2).

Bottom Line: LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members.LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence.In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.

ABSTRACT
LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members. In this study, we showed that LIN28B expression promotes migration and recurrence of colon cancer. Immunohistochemistry and reverse-transcription polymerase chain reactions were performed to detect LIN28B expression in colon cancer tissue microarrays, paraffin-embedded surgical resected tissues and cancer cells. Loss-of-function, migration and proliferation analyses were performed to delineate the potential roles of LIN28B in colon cancer. LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence. LIN28B suppression inhibited the migration of SW480 colon cancer cells and facilitated the cytotoxicity induced by oxaliplatin in SW480 and HCT116 colon cancer cells. In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.

Show MeSH
Related in: MedlinePlus