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Ciprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization.

Sombié BC, Yameogo JG, Semdé R, Henschel V, Amighi K, Goole J - J Adv Pharm Technol Res (2014)

Bottom Line: This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride.Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics.Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Pharmaceutical Sciences, UFR/SDS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso, Belgium.

ABSTRACT
This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride. Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics. Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form. However, despite its insolubility, microscopic observation, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and X-ray diffraction showed that the developed gel was in the cubic liquid crystalline structure and have maintained their ability to progressively release ciprofloxacin. ciprofloxacin-monoolein-water (5:80:15% w/w), which released in vitro approximately 85% of ciprofloxacin after 16 days could possibly be considered as an alternative to a gentamicin-monoolein-water gel for the treatment of chronic osteomyelitis.

No MeSH data available.


Related in: MedlinePlus

Pictures from the optical microscope at ×500 magnification with polarized light of the ciprofloxacin (1 and 2), gentamicin (3 and 4) and REF monoolein water gels
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Figure 2: Pictures from the optical microscope at ×500 magnification with polarized light of the ciprofloxacin (1 and 2), gentamicin (3 and 4) and REF monoolein water gels

Mentions: Microscopic observation under polarized lens at 25°C [Figure 2] showed that the developed Gels were characterized by a liquid crystalline structure which corresponded to previous observations made by different authors.[19202122] As expected, due to their high viscosity [Table 2] and their isotropic nature, the liquid crystals of the gels were in a cubic phase.[820] In addition, rod-shaped particles of undissolved ciprofloxacin hydrochloride were observed in Gels 1 and 2. However, it has been reported that the incorporation of insoluble drug in a cubic phase did not cause a change in the structure.[21]


Ciprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization.

Sombié BC, Yameogo JG, Semdé R, Henschel V, Amighi K, Goole J - J Adv Pharm Technol Res (2014)

Pictures from the optical microscope at ×500 magnification with polarized light of the ciprofloxacin (1 and 2), gentamicin (3 and 4) and REF monoolein water gels
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215478&req=5

Figure 2: Pictures from the optical microscope at ×500 magnification with polarized light of the ciprofloxacin (1 and 2), gentamicin (3 and 4) and REF monoolein water gels
Mentions: Microscopic observation under polarized lens at 25°C [Figure 2] showed that the developed Gels were characterized by a liquid crystalline structure which corresponded to previous observations made by different authors.[19202122] As expected, due to their high viscosity [Table 2] and their isotropic nature, the liquid crystals of the gels were in a cubic phase.[820] In addition, rod-shaped particles of undissolved ciprofloxacin hydrochloride were observed in Gels 1 and 2. However, it has been reported that the incorporation of insoluble drug in a cubic phase did not cause a change in the structure.[21]

Bottom Line: This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride.Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics.Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Pharmaceutical Sciences, UFR/SDS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso, Belgium.

ABSTRACT
This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride. Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics. Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form. However, despite its insolubility, microscopic observation, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and X-ray diffraction showed that the developed gel was in the cubic liquid crystalline structure and have maintained their ability to progressively release ciprofloxacin. ciprofloxacin-monoolein-water (5:80:15% w/w), which released in vitro approximately 85% of ciprofloxacin after 16 days could possibly be considered as an alternative to a gentamicin-monoolein-water gel for the treatment of chronic osteomyelitis.

No MeSH data available.


Related in: MedlinePlus