Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.
Bottom Line: The time to first confirmed relapse was increased with ponesimod compared with placebo.Once-daily treatment with ponesimod 10, 20 or 40 mg significantly reduced the number of new T1 Gd+ lesions and showed a beneficial effect on clinical endpoints.NCT01006265.
Affiliation: Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.Show MeSH
Related in: MedlinePlus
Mentions: Lymphocyte counts were rapidly reduced with ponesimod treatment in a dose-dependent manner (figure 5A). Following initial treatment (up-titration) with ponesimod 10 mg, the mean decrease from baseline to day 8 (predose) in lymphocyte count ranged from 43% to 45% in all ponesimod groups and was 1% in the placebo group. Following up-titration to 20 mg on day 8, the mean decrease from baseline to day 15 (predose) in lymphocyte count was 62% for both the ponesimod 20 and 40 mg groups. Following up-titration to 40 mg on day 15, the mean decrease from baseline to week 4 in lymphocyte count was 67% in the ponesimod 40 mg group. Mean reductions from baseline to week 24 were 50%, 65% and 69% for ponesimod 10, 20 and 40 mg, respectively, and 3% in the placebo group.
Affiliation: Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.