Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.
Bottom Line: The time to first confirmed relapse was increased with ponesimod compared with placebo.Once-daily treatment with ponesimod 10, 20 or 40 mg significantly reduced the number of new T1 Gd+ lesions and showed a beneficial effect on clinical endpoints.NCT01006265.
Affiliation: Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.Show MeSH
Related in: MedlinePlus
Mentions: Study design is summarised in figure 1. All patients randomised to ponesimod initially received ponesimod 10 mg (days 1–7). On day 8, patients randomised to receive ponesimod 20 or 40 mg were up-titrated to the 20 mg dose and patients randomised to the 10 mg dose were mock up-titrated. On day 15, patients randomised to receive ponesimod 40 mg were up-titrated to the 40 mg dose; patients randomised to ponesimod 10 or 20 mg were mock up-titrated. Patients randomised to placebo were mock up-titrated on days 8 and 15 (figure 1).
Affiliation: Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.