LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.
Bottom Line: Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.LncRNAs showed significantly altered expression in OSCC tissues.Our results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.Show MeSH
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Mentions: To compare the sensitivity and specificity in survival prediction between TNM stage and the three-lncRNA signature, we performed receiver operating characteristic (ROC) analysis (see online supplementary methods).20 We also constructed a prognostic model combining the two factors and compared the predictive ability. In the training set, predictive ability of both three-lncRNA signature and the combined model were significantly better than TNM stage alone (p=0.0268, p=0.0006, respectively, figure 5A). In the test set, no significantly different predictive ability between the TNM stage and the signature was found. The combined model had a higher area under the ROC curve than the TNM stage (0.71 vs 0.63, figure 5B); however, the difference was not significant (p=0.1256), probably owing to limited sample size. ROC analysis was not performed for the independent cohort because the follow-up period of these patients was <5 years.
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.