LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.
Bottom Line: Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.LncRNAs showed significantly altered expression in OSCC tissues.Our results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.Show MeSH
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Mentions: We next carried out a stratified analysis in TNM stage II and III patients to evaluate whether the three-lncRNA signature could predict survival of patients within the same clinical stage. Log-rank test of stage II patients in both the training group (p<0.0001, figure 4A) and the combination of test and independent cohort (p=0.0257, figure 4B) showed that the signature could classify stage II patients with OSCC into high- and low-risk groups. For patients with stage III OSCC, the three-lncRNA signature showed similar prognostic value in the training (p=0.0104, figure 4C) and the combined test and independent (p=0.0105, figure 4D) datasets. Because of limited sample size (n=10), the stratified analysis was not performed for stage I patients.
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.