LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.
Bottom Line: Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.LncRNAs showed significantly altered expression in OSCC tissues.Our results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.Show MeSH
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Mentions: We first compared the lncRNA expression profiles of OSCC tissues and adjacent normal tissues using unsupervised hierarchical clustering in 119 patients. In total, 6389 lncRNAs with a coefficient of variance >0.10 were selected from the 8900 lncRNAs for clustering analysis. Hierarchical clustering of these 6389 lncRNAs based on centred Pearson correlation clearly separated OSCC tissues from normal tissues (figure 2). Only 12 samples (six tumour samples and six normal samples) were misclassified by the clustering analysis. Among all the lncRNAs, 799 showed at least a twofold change in the OSCC tissues compared with the normal tissues (355 being upregulated and 444 downregulated).
Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.