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LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.

Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, Wang S, Zhou F, Shi S, Feng X, Sun N, Liu Z, Skogerboe G, Dong J, Yao R, Zhao Y, Sun J, Zhang B, Yu Y, Shi X, Luo M, Shao K, Li N, Qiu B, Tan F, Chen R, He J - Gut (2014)

Bottom Line: Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.LncRNAs showed significantly altered expression in OSCC tissues.Our results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.

View Article: PubMed Central - PubMed

Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.

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Unsupervised hierarchical clustering of the 119 pairs of tissues. The normalised expression data of the 6389 lncRNAs with coefficient of variance >0.10 was used for clustering analysis. Hierarchical clustering clearly separated tumour (blue bar) and normal (yellow bar) samples. Only six tumour samples and six normal samples were misclassified.
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GUTJNL2013305806F2: Unsupervised hierarchical clustering of the 119 pairs of tissues. The normalised expression data of the 6389 lncRNAs with coefficient of variance >0.10 was used for clustering analysis. Hierarchical clustering clearly separated tumour (blue bar) and normal (yellow bar) samples. Only six tumour samples and six normal samples were misclassified.

Mentions: We first compared the lncRNA expression profiles of OSCC tissues and adjacent normal tissues using unsupervised hierarchical clustering in 119 patients. In total, 6389 lncRNAs with a coefficient of variance >0.10 were selected from the 8900 lncRNAs for clustering analysis. Hierarchical clustering of these 6389 lncRNAs based on centred Pearson correlation clearly separated OSCC tissues from normal tissues (figure 2). Only 12 samples (six tumour samples and six normal samples) were misclassified by the clustering analysis. Among all the lncRNAs, 799 showed at least a twofold change in the OSCC tissues compared with the normal tissues (355 being upregulated and 444 downregulated).


LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.

Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, Wang S, Zhou F, Shi S, Feng X, Sun N, Liu Z, Skogerboe G, Dong J, Yao R, Zhao Y, Sun J, Zhang B, Yu Y, Shi X, Luo M, Shao K, Li N, Qiu B, Tan F, Chen R, He J - Gut (2014)

Unsupervised hierarchical clustering of the 119 pairs of tissues. The normalised expression data of the 6389 lncRNAs with coefficient of variance >0.10 was used for clustering analysis. Hierarchical clustering clearly separated tumour (blue bar) and normal (yellow bar) samples. Only six tumour samples and six normal samples were misclassified.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215280&req=5

GUTJNL2013305806F2: Unsupervised hierarchical clustering of the 119 pairs of tissues. The normalised expression data of the 6389 lncRNAs with coefficient of variance >0.10 was used for clustering analysis. Hierarchical clustering clearly separated tumour (blue bar) and normal (yellow bar) samples. Only six tumour samples and six normal samples were misclassified.
Mentions: We first compared the lncRNA expression profiles of OSCC tissues and adjacent normal tissues using unsupervised hierarchical clustering in 119 patients. In total, 6389 lncRNAs with a coefficient of variance >0.10 were selected from the 8900 lncRNAs for clustering analysis. Hierarchical clustering of these 6389 lncRNAs based on centred Pearson correlation clearly separated OSCC tissues from normal tissues (figure 2). Only 12 samples (six tumour samples and six normal samples) were misclassified by the clustering analysis. Among all the lncRNAs, 799 showed at least a twofold change in the OSCC tissues compared with the normal tissues (355 being upregulated and 444 downregulated).

Bottom Line: Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.LncRNAs showed significantly altered expression in OSCC tissues.Our results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.

View Article: PubMed Central - PubMed

Affiliation: ! Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, The People's Republic of China.

Show MeSH
Related in: MedlinePlus