Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.
Bottom Line: We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy.
Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.Show MeSH
Related in: MedlinePlus
Mentions: The mean values of the mtDNA content in the six controls and six patients are reported in figure 4. The mtDNA copy numbers of the six control muscles detected by our quantification system were consistent with the results reported by David Dimmock and his colleagues.14 Statistically significant difference was found in the mean value of mtDNA/nDNA ratio between the six controls (mean±SD=1891.76±815.18) and six patients (mean±SD=546.45±382.14) (p<0.01). In the six patients, the mtDNA content was reduced to less than 30% in comparison with the six controls.
Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.