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Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.

Xu H, Wang Z, Zheng L, Zhang W, Lv H, Jin S, Yuan Y - J. Clin. Pathol. (2014)

Bottom Line: We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.

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Related in: MedlinePlus

Demyelination, axonal degeneration and homogeneous staining of the mitochondria in neuropathy during the treatment of lamivudine/telbivudine. (A) Reduction of myelinated nerve fibres, axonal degeneration (arrow) in patient 1. (B) Axonal degeneration (arrow) and Wallerian degeneration (arrowhead) in patient 1 (electron microscope (EM), 8000×). Mitochondria with homogenised matrix (arrow) were observed in the myelinated axons in patient 5 (EM, 80 000×) (C), unmyelinated axons (arrow) in patient 1 (EM, 50 000×) (D).
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JCLINPATH2013202069F3: Demyelination, axonal degeneration and homogeneous staining of the mitochondria in neuropathy during the treatment of lamivudine/telbivudine. (A) Reduction of myelinated nerve fibres, axonal degeneration (arrow) in patient 1. (B) Axonal degeneration (arrow) and Wallerian degeneration (arrowhead) in patient 1 (electron microscope (EM), 8000×). Mitochondria with homogenised matrix (arrow) were observed in the myelinated axons in patient 5 (EM, 80 000×) (C), unmyelinated axons (arrow) in patient 1 (EM, 50 000×) (D).

Mentions: Sural biopsies demonstrated moderate reduction of myelinated nerve fibres with axonal degeneration and occasionally regenerated cluster (table 3) (figure 3A). In patient 5, several demyelinated fibres can be observed, but no onion bulb formation. No inflammatory cell infiltration can be observed around vessels or in the epineurium.


Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.

Xu H, Wang Z, Zheng L, Zhang W, Lv H, Jin S, Yuan Y - J. Clin. Pathol. (2014)

Demyelination, axonal degeneration and homogeneous staining of the mitochondria in neuropathy during the treatment of lamivudine/telbivudine. (A) Reduction of myelinated nerve fibres, axonal degeneration (arrow) in patient 1. (B) Axonal degeneration (arrow) and Wallerian degeneration (arrowhead) in patient 1 (electron microscope (EM), 8000×). Mitochondria with homogenised matrix (arrow) were observed in the myelinated axons in patient 5 (EM, 80 000×) (C), unmyelinated axons (arrow) in patient 1 (EM, 50 000×) (D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215273&req=5

JCLINPATH2013202069F3: Demyelination, axonal degeneration and homogeneous staining of the mitochondria in neuropathy during the treatment of lamivudine/telbivudine. (A) Reduction of myelinated nerve fibres, axonal degeneration (arrow) in patient 1. (B) Axonal degeneration (arrow) and Wallerian degeneration (arrowhead) in patient 1 (electron microscope (EM), 8000×). Mitochondria with homogenised matrix (arrow) were observed in the myelinated axons in patient 5 (EM, 80 000×) (C), unmyelinated axons (arrow) in patient 1 (EM, 50 000×) (D).
Mentions: Sural biopsies demonstrated moderate reduction of myelinated nerve fibres with axonal degeneration and occasionally regenerated cluster (table 3) (figure 3A). In patient 5, several demyelinated fibres can be observed, but no onion bulb formation. No inflammatory cell infiltration can be observed around vessels or in the epineurium.

Bottom Line: We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.

Show MeSH
Related in: MedlinePlus