Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.
Bottom Line: We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy.
Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.Show MeSH
Related in: MedlinePlus
Mentions: Sural biopsies demonstrated moderate reduction of myelinated nerve fibres with axonal degeneration and occasionally regenerated cluster (table 3) (figure 3A). In patient 5, several demyelinated fibres can be observed, but no onion bulb formation. No inflammatory cell infiltration can be observed around vessels or in the epineurium.
Affiliation: Department of Neurology, Peking University First Hospital, Beijing, PR China.