High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
Bottom Line: The association between higher proportions of FOXP3(+) CD25(high) T cells and sensitization persisted after exclusion of farmer's children.Finally, a farming environment was associated with lower proportions of FOXP3(+) CD25(high) T cells in early infancy and to a more prominent T cell memory conversion and cytokine production.Our results indicate that high proportions of FOXP3(+) CD25(high) T cells in neonates are not protective against later sensitization or development of allergy.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Show MeSH
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Mentions: Although allergy is linked to sensitization, children may be allergic but not sensitized, as wellas sensitized but not allergic (Table1). Hence, we examinedhow the T cell variables described above were related to allergic disease at 18 and 36 monthsof age. The OPLS-DA loadings column plot in Fig.3a is basedon parameters with VIP values ≥ 0.9. Being allergic at 36 months of age wasassociated with mononuclear cells with a higher capacity to produce the Th2-related cytokines IL-5and IL-13 at both 18 and 36 months of life. However, no T cell variables were inverselyrelated to allergic disease. Univariate analyses confirmed that allergic children producedsignificantly higher levels of IL-5 upon PHA stimulation at 36, but not at 18 months of age(Fig.3b). A clinical diagnosis of allergy at18 months of age did not display any specific association patterns with the T cell variables(data not shown). These results suggest that, in contrast to sensitization, a clinical diagnosis ofallergy is not associated with higher proportions of neonatalFOXP3+CD25high putative Tregs within the CD4+ T cellpopulation. Moreover, as one could expect, being allergic is related to a higher capacity to producethe Th2-related cytokine IL-5.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.