High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
Bottom Line: A clinical evaluation regarding the presence of allergen-specific IgE and allergy was performed at 18 and 36 months of age.Multivariate discriminant analysis revealed that children who were sensitized at 18 or 36 months of age had higher proportions of FOXP3(+) CD25(high) T cells at birth and at 3 days of life than children who remained non-sensitized, whereas allergy was unrelated to the neonatal proportions of these cells.Finally, a farming environment was associated with lower proportions of FOXP3(+) CD25(high) T cells in early infancy and to a more prominent T cell memory conversion and cytokine production.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Show MeSH
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Mentions: Although allergy is linked to sensitization, children may be allergic but not sensitized, as wellas sensitized but not allergic (Table1). Hence, we examinedhow the T cell variables described above were related to allergic disease at 18 and 36 monthsof age. The OPLS-DA loadings column plot in Fig.3a is basedon parameters with VIP values ≥ 0.9. Being allergic at 36 months of age wasassociated with mononuclear cells with a higher capacity to produce the Th2-related cytokines IL-5and IL-13 at both 18 and 36 months of life. However, no T cell variables were inverselyrelated to allergic disease. Univariate analyses confirmed that allergic children producedsignificantly higher levels of IL-5 upon PHA stimulation at 36, but not at 18 months of age(Fig.3b). A clinical diagnosis of allergy at18 months of age did not display any specific association patterns with the T cell variables(data not shown). These results suggest that, in contrast to sensitization, a clinical diagnosis ofallergy is not associated with higher proportions of neonatalFOXP3+CD25high putative Tregs within the CD4+ T cellpopulation. Moreover, as one could expect, being allergic is related to a higher capacity to producethe Th2-related cytokine IL-5.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.