High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
Bottom Line: A clinical evaluation regarding the presence of allergen-specific IgE and allergy was performed at 18 and 36 months of age.Multivariate discriminant analysis revealed that children who were sensitized at 18 or 36 months of age had higher proportions of FOXP3(+) CD25(high) T cells at birth and at 3 days of life than children who remained non-sensitized, whereas allergy was unrelated to the neonatal proportions of these cells.Finally, a farming environment was associated with lower proportions of FOXP3(+) CD25(high) T cells in early infancy and to a more prominent T cell memory conversion and cytokine production.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Show MeSH
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Mentions: Using multivariate discriminant analysis by OPLS (orthogonal projections to latent structures),we investigated sensitization at 18 or 36 months of age in relation to proportions ofCD4+ T cell subsets (FOXP3+CD25high,CTLA-4+CD25+, CD45RO+,HLA-DR+, CCR4+ and α4β7+) atbirth, 3–5 days of age and at 1, 4, 18 and 36 months of age, as well ascytokine production (IL-1β, TNF, IL-6, IFN-γ, IL-5 and IL-13) by peripheral bloodmononuclear cells after stimulation with PHA (at 4, 18 and 36 months of age), birch allergenextract or ovalbumin (at 36 months of age). For sensitization at 18 months of age,immune parameters measured at 36 months were not included in the analysis. The OPLS-DAscatter plots, in Figs1a and b, indicated that children whowere sensitized (filled circles) and non-sensitized (open circles) at 18 or 36 months of age,respectively, could be separated based on the T cell variables described above.
Affiliation: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.