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Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

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Clinical relevance of SPT reactions for hazel, dog, and Dermatophagoides pteronyssinus by age group, gender, and region. Solid line shows the estimated proportion of patients with clinical symptoms. X-axis shows the diameter of the SPT wheal in mm.
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fig03: Clinical relevance of SPT reactions for hazel, dog, and Dermatophagoides pteronyssinus by age group, gender, and region. Solid line shows the estimated proportion of patients with clinical symptoms. X-axis shows the diameter of the SPT wheal in mm.

Mentions: To determine differences in clinical relevance of sensitizations subgroup, analyses were performed by age, gender, and region. The prevalence of allergic symptoms for the subgroups is shown for hazel, dog, and Dp (Fig.3), the three allergens with enough positive reactions to make subgroup analysis. SPT-positive children were clearly less frequently symptomatic than SPT-positive adults in relation to hazel (42 vs. 81%, P < 0.001) and dog allergens (28 vs. 61%, P < 0.001), with no difference in relation to house dust mites (Fig.3). However, the relationship of more frequent symptoms in case of larger wheals remained. The frequency of symptoms was slightly higher among SPT-positive women compared with SPT-positive men in relation to wheal sizes for hazel (80 vs. 71%, P = 0.012), dog (61 vs. 52%, P = 0.031), and Dp (87 vs. 83%, P = 0.064) (Fig.3). In the regional analyses, there was a lower frequency of symptoms in the Mediterranean vs. Nordic or Central European regions in relation to positive SPTs to hazel and dog allergens (Fig.3). No regional differences were found for grass or house dust mite.


Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Clinical relevance of SPT reactions for hazel, dog, and Dermatophagoides pteronyssinus by age group, gender, and region. Solid line shows the estimated proportion of patients with clinical symptoms. X-axis shows the diameter of the SPT wheal in mm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215109&req=5

fig03: Clinical relevance of SPT reactions for hazel, dog, and Dermatophagoides pteronyssinus by age group, gender, and region. Solid line shows the estimated proportion of patients with clinical symptoms. X-axis shows the diameter of the SPT wheal in mm.
Mentions: To determine differences in clinical relevance of sensitizations subgroup, analyses were performed by age, gender, and region. The prevalence of allergic symptoms for the subgroups is shown for hazel, dog, and Dp (Fig.3), the three allergens with enough positive reactions to make subgroup analysis. SPT-positive children were clearly less frequently symptomatic than SPT-positive adults in relation to hazel (42 vs. 81%, P < 0.001) and dog allergens (28 vs. 61%, P < 0.001), with no difference in relation to house dust mites (Fig.3). However, the relationship of more frequent symptoms in case of larger wheals remained. The frequency of symptoms was slightly higher among SPT-positive women compared with SPT-positive men in relation to wheal sizes for hazel (80 vs. 71%, P = 0.012), dog (61 vs. 52%, P = 0.031), and Dp (87 vs. 83%, P = 0.064) (Fig.3). In the regional analyses, there was a lower frequency of symptoms in the Mediterranean vs. Nordic or Central European regions in relation to positive SPTs to hazel and dog allergens (Fig.3). No regional differences were found for grass or house dust mite.

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

Show MeSH
Related in: MedlinePlus