Clinical relevance is associated with allergen-specific wheal size in skin prick testing.
Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.
Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.Show MeSH
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Mentions: The wheal sizes of SPT with hazel, birch, grass, cat, dog, and Dp in relation to the percentage of patients with physician-diagnosed allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy are shown in Fig.2. Overall, in patients with positive SPTs, and one or more diagnosis, allergic rhinitis was by far the most prevalent disorder – 80–90% of SPT-positive patients had rhinitis. Allergic asthma was present in 30–40% and atopic dermatitis or food allergies in 10–20% of those with positive SPTs. For Dp, a clear increase in diagnosed asthma and rhinitis was seen with larger wheal sizes (Fig.2). Similarly, larger wheal sizes in SPT for birch, cat, and dog were associated with higher rates of atopic dermatitis (Fig.2).
Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.