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Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

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Related in: MedlinePlus

Clinical relevance of SPT reactions according to physician-made diagnosis: allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy. Solid line shows the estimated proportion of patients with diagnosis. X-axis shows the diameter of the SPT wheal in mm.
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fig02: Clinical relevance of SPT reactions according to physician-made diagnosis: allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy. Solid line shows the estimated proportion of patients with diagnosis. X-axis shows the diameter of the SPT wheal in mm.

Mentions: The wheal sizes of SPT with hazel, birch, grass, cat, dog, and Dp in relation to the percentage of patients with physician-diagnosed allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy are shown in Fig.2. Overall, in patients with positive SPTs, and one or more diagnosis, allergic rhinitis was by far the most prevalent disorder – 80–90% of SPT-positive patients had rhinitis. Allergic asthma was present in 30–40% and atopic dermatitis or food allergies in 10–20% of those with positive SPTs. For Dp, a clear increase in diagnosed asthma and rhinitis was seen with larger wheal sizes (Fig.2). Similarly, larger wheal sizes in SPT for birch, cat, and dog were associated with higher rates of atopic dermatitis (Fig.2).


Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Clinical relevance of SPT reactions according to physician-made diagnosis: allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy. Solid line shows the estimated proportion of patients with diagnosis. X-axis shows the diameter of the SPT wheal in mm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215109&req=5

fig02: Clinical relevance of SPT reactions according to physician-made diagnosis: allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy. Solid line shows the estimated proportion of patients with diagnosis. X-axis shows the diameter of the SPT wheal in mm.
Mentions: The wheal sizes of SPT with hazel, birch, grass, cat, dog, and Dp in relation to the percentage of patients with physician-diagnosed allergic rhinitis, allergic asthma, atopic dermatitis, and food allergy are shown in Fig.2. Overall, in patients with positive SPTs, and one or more diagnosis, allergic rhinitis was by far the most prevalent disorder – 80–90% of SPT-positive patients had rhinitis. Allergic asthma was present in 30–40% and atopic dermatitis or food allergies in 10–20% of those with positive SPTs. For Dp, a clear increase in diagnosed asthma and rhinitis was seen with larger wheal sizes (Fig.2). Similarly, larger wheal sizes in SPT for birch, cat, and dog were associated with higher rates of atopic dermatitis (Fig.2).

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

Show MeSH
Related in: MedlinePlus