Clinical relevance is associated with allergen-specific wheal size in skin prick testing.
Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.
Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.Show MeSH
Related in: MedlinePlus
Mentions: The relationship between SPT wheal sizes and the percentage of patients with allergic symptoms are shown for all 18 allergens (Fig.1). In general, with increasing wheal sizes, the prevalence of allergic symptoms increased. Depending on the allergen, from 40% (blatella) to 87–89% (grass, Dp) of the positive SPT reactions (3 mm or more) were associated with patient-reported clinical symptoms. The relationship between the allergic symptoms and the wheal size in each of these 18 allergens expressed as crude odds ratios is shown in Table1. With the exception of Aspergillus fumigatus, a larger wheal size significantly increased the risk of having symptoms.
Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.