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Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

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Related in: MedlinePlus

Clinical relevance of positive SPT reactions (wheal size 3 mm or more) of 18 common inhalant allergens in Europe. Solid line shows the estimated proportion of patients with symptoms and dotted lines 95% confidence intervals. Positive predictive value (%) is shown in each panel.
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fig01: Clinical relevance of positive SPT reactions (wheal size 3 mm or more) of 18 common inhalant allergens in Europe. Solid line shows the estimated proportion of patients with symptoms and dotted lines 95% confidence intervals. Positive predictive value (%) is shown in each panel.

Mentions: The relationship between SPT wheal sizes and the percentage of patients with allergic symptoms are shown for all 18 allergens (Fig.1). In general, with increasing wheal sizes, the prevalence of allergic symptoms increased. Depending on the allergen, from 40% (blatella) to 87–89% (grass, Dp) of the positive SPT reactions (3 mm or more) were associated with patient-reported clinical symptoms. The relationship between the allergic symptoms and the wheal size in each of these 18 allergens expressed as crude odds ratios is shown in Table1. With the exception of Aspergillus fumigatus, a larger wheal size significantly increased the risk of having symptoms.


Clinical relevance is associated with allergen-specific wheal size in skin prick testing.

Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Köhli A, Wöhrl S, Järvenpää S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM - Clin. Exp. Allergy (2014)

Clinical relevance of positive SPT reactions (wheal size 3 mm or more) of 18 common inhalant allergens in Europe. Solid line shows the estimated proportion of patients with symptoms and dotted lines 95% confidence intervals. Positive predictive value (%) is shown in each panel.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215109&req=5

fig01: Clinical relevance of positive SPT reactions (wheal size 3 mm or more) of 18 common inhalant allergens in Europe. Solid line shows the estimated proportion of patients with symptoms and dotted lines 95% confidence intervals. Positive predictive value (%) is shown in each panel.
Mentions: The relationship between SPT wheal sizes and the percentage of patients with allergic symptoms are shown for all 18 allergens (Fig.1). In general, with increasing wheal sizes, the prevalence of allergic symptoms increased. Depending on the allergen, from 40% (blatella) to 87–89% (grass, Dp) of the positive SPT reactions (3 mm or more) were associated with patient-reported clinical symptoms. The relationship between the allergic symptoms and the wheal size in each of these 18 allergens expressed as crude odds ratios is shown in Table1. With the exception of Aspergillus fumigatus, a larger wheal size significantly increased the risk of having symptoms.

Bottom Line: The effects of age, gender, and geographical area on SPT results were assessed.Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults.These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance.

View Article: PubMed Central - PubMed

Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

Show MeSH
Related in: MedlinePlus