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Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review.

Mohammadi Z, Fayyazbakhsh F, Ebrahimi M, Amoli MM, Khashayar P, Dini M, Zadeh RN, Keshtkar A, Barikani HR - J Diabetes Metab Disord (2014)

Bottom Line: However, many studies have not been able to find this association.Literature review was conducted in several databases, including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for papers published between 2000 and 2013 describing the association between Fok1 and Bsm1 polymorphisms of the VDR gene and osteoporosis risk.The majority of the revealed papers were conducted on postmenopausal women.

View Article: PubMed Central - PubMed

Affiliation: Department of biology, Damghan branch, Islamic Azad University, Damghan, Iran.

ABSTRACT
Osteoporosis is a health concern characterized by reduced bone mineral density (BMD) and increased risk of fragility fractures. Many studies have investigated the association between genetic variants and osteoporosis. Polymorphism and allelic variations in the vitamin D receptor gene (VDR) have been found to be associated with bone mineral density. However, many studies have not been able to find this association. Literature review was conducted in several databases, including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for papers published between 2000 and 2013 describing the association between Fok1 and Bsm1 polymorphisms of the VDR gene and osteoporosis risk. The majority of the revealed papers were conducted on postmenopausal women. Also, more than 50% studies reported significant relation between Fok1, Bsm1 and osteoporosis. Larger and more rigorous analytical studies with consideration of gene-gene and gene-environment interactions are needed to further dissect the mechanisms by which VDR polymorphisms influence osteoporosis.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of the literature search.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Fig1: Flow diagram of the literature search.

Mentions: A schematic of the literature search is shown in Figure 1. According to the inclusion/exclusion criteria eligibility, 61 articles were identified regarding the associations between the Fok1 and Bsm1 polymorphisms of VDR gene and osteoporosis risk. Among these studies, 21 studies concerned the association of the Fok1 polymorphism with osteoporosis [9,72-91], while 26 studies investigated the association between Bsm1polymorphism and osteoporosis risk [92-117]. Also 14 articles evaluated both polymorphism associations with osteoporosis [118-131]. All of these 61 studies provided sufficient data to calculate the possible relationship between the two polymorphisms of the VDR gene and osteoporosis risk. The general characteristics of the selected studies are summarized in Table 1.Figure 1


Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review.

Mohammadi Z, Fayyazbakhsh F, Ebrahimi M, Amoli MM, Khashayar P, Dini M, Zadeh RN, Keshtkar A, Barikani HR - J Diabetes Metab Disord (2014)

Flow diagram of the literature search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4215021&req=5

Fig1: Flow diagram of the literature search.
Mentions: A schematic of the literature search is shown in Figure 1. According to the inclusion/exclusion criteria eligibility, 61 articles were identified regarding the associations between the Fok1 and Bsm1 polymorphisms of VDR gene and osteoporosis risk. Among these studies, 21 studies concerned the association of the Fok1 polymorphism with osteoporosis [9,72-91], while 26 studies investigated the association between Bsm1polymorphism and osteoporosis risk [92-117]. Also 14 articles evaluated both polymorphism associations with osteoporosis [118-131]. All of these 61 studies provided sufficient data to calculate the possible relationship between the two polymorphisms of the VDR gene and osteoporosis risk. The general characteristics of the selected studies are summarized in Table 1.Figure 1

Bottom Line: However, many studies have not been able to find this association.Literature review was conducted in several databases, including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for papers published between 2000 and 2013 describing the association between Fok1 and Bsm1 polymorphisms of the VDR gene and osteoporosis risk.The majority of the revealed papers were conducted on postmenopausal women.

View Article: PubMed Central - PubMed

Affiliation: Department of biology, Damghan branch, Islamic Azad University, Damghan, Iran.

ABSTRACT
Osteoporosis is a health concern characterized by reduced bone mineral density (BMD) and increased risk of fragility fractures. Many studies have investigated the association between genetic variants and osteoporosis. Polymorphism and allelic variations in the vitamin D receptor gene (VDR) have been found to be associated with bone mineral density. However, many studies have not been able to find this association. Literature review was conducted in several databases, including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for papers published between 2000 and 2013 describing the association between Fok1 and Bsm1 polymorphisms of the VDR gene and osteoporosis risk. The majority of the revealed papers were conducted on postmenopausal women. Also, more than 50% studies reported significant relation between Fok1, Bsm1 and osteoporosis. Larger and more rigorous analytical studies with consideration of gene-gene and gene-environment interactions are needed to further dissect the mechanisms by which VDR polymorphisms influence osteoporosis.

No MeSH data available.


Related in: MedlinePlus