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Long-term Effects of Specific Allergen Immunotherapy Against House Dust Mites in Polysensitized Patients With Allergic Rhinitis.

Kim SH, Shin SY, Lee KH, Kim SW, Cho JS - Allergy Asthma Immunol Res (2014)

Bottom Line: We evaluated the effectiveness of immunotherapy against house dust mites (HDMs) in AR patients polysensitized to both HDMs and seasonal allergens.There were no statistical differences in levels of total and specific IgE, or total eosinophil count between the two groups.We determined that the primary causative allergen of AR in Seoul, Korea is perennial allergens, such as HDMs, rather than seasonal allergens.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: Allergen-specific immunotherapy is the only currently available treatment to modify the natural history of allergic rhinitis (AR). If patients are polysensitized, it is difficult to identify the allergen causing the allergic symptoms. We evaluated the effectiveness of immunotherapy against house dust mites (HDMs) in AR patients polysensitized to both HDMs and seasonal allergens.

Methods: Thirty AR patients polysensitized to both HDMs and seasonal allergens (group A) and 30 patients sensitized to HDMs only (group B) were enrolled in this study. All subjects who received immunotherapy against HDMs for more than 2 years were evaluated by the multiple allergen simultaneous test (MAST) to determine the specific IgE level in luminescence units, total eosinophil counts in peripheral blood, serum total IgE, total nasal symptom scores, and the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after immunotherapy.

Results: There were no statistical differences in levels of total and specific IgE, or total eosinophil count between the two groups. The total nasal symptom scores, RQLQ and medication scores significantly decreased after immunotherapy in both groups, however no significant differences were noted between the two groups.

Conclusions: We determined that the primary causative allergen of AR in Seoul, Korea is perennial allergens, such as HDMs, rather than seasonal allergens. This study provides a reference for the selection of allergens to use in immunotherapy for polysensitized AR patients living in an urban environment.

No MeSH data available.


Related in: MedlinePlus

Comparison of total nasal symptom scores pre- and post-treatment between Groups A and B (*P<0.05).
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Figure 2: Comparison of total nasal symptom scores pre- and post-treatment between Groups A and B (*P<0.05).

Mentions: Total nasal symptom scores were 11.8 in group A and 11.3 in group B, with no difference between the 2 groups. After immunotherapy, total scores were 3.8 and 3.2, respectively, with a significant decrease in both groups after immunotherapy but no difference between the 2 groups (Fig. 2). The average life quality score was 62.4 in group A and 59.7 in group B, showing no significant difference between the 2 groups. After immunotherapy, life quality scores were 22.8 and 20.3, respectively, which were significantly decreased in both groups relative to before immunotherapy, but there was no difference between the 2 groups (Fig. 3). Mean medication scores also showed a significant decrease in both groups after immunotherapy but no difference between the 2 groups (Fig. 4).


Long-term Effects of Specific Allergen Immunotherapy Against House Dust Mites in Polysensitized Patients With Allergic Rhinitis.

Kim SH, Shin SY, Lee KH, Kim SW, Cho JS - Allergy Asthma Immunol Res (2014)

Comparison of total nasal symptom scores pre- and post-treatment between Groups A and B (*P<0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214974&req=5

Figure 2: Comparison of total nasal symptom scores pre- and post-treatment between Groups A and B (*P<0.05).
Mentions: Total nasal symptom scores were 11.8 in group A and 11.3 in group B, with no difference between the 2 groups. After immunotherapy, total scores were 3.8 and 3.2, respectively, with a significant decrease in both groups after immunotherapy but no difference between the 2 groups (Fig. 2). The average life quality score was 62.4 in group A and 59.7 in group B, showing no significant difference between the 2 groups. After immunotherapy, life quality scores were 22.8 and 20.3, respectively, which were significantly decreased in both groups relative to before immunotherapy, but there was no difference between the 2 groups (Fig. 3). Mean medication scores also showed a significant decrease in both groups after immunotherapy but no difference between the 2 groups (Fig. 4).

Bottom Line: We evaluated the effectiveness of immunotherapy against house dust mites (HDMs) in AR patients polysensitized to both HDMs and seasonal allergens.There were no statistical differences in levels of total and specific IgE, or total eosinophil count between the two groups.We determined that the primary causative allergen of AR in Seoul, Korea is perennial allergens, such as HDMs, rather than seasonal allergens.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: Allergen-specific immunotherapy is the only currently available treatment to modify the natural history of allergic rhinitis (AR). If patients are polysensitized, it is difficult to identify the allergen causing the allergic symptoms. We evaluated the effectiveness of immunotherapy against house dust mites (HDMs) in AR patients polysensitized to both HDMs and seasonal allergens.

Methods: Thirty AR patients polysensitized to both HDMs and seasonal allergens (group A) and 30 patients sensitized to HDMs only (group B) were enrolled in this study. All subjects who received immunotherapy against HDMs for more than 2 years were evaluated by the multiple allergen simultaneous test (MAST) to determine the specific IgE level in luminescence units, total eosinophil counts in peripheral blood, serum total IgE, total nasal symptom scores, and the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after immunotherapy.

Results: There were no statistical differences in levels of total and specific IgE, or total eosinophil count between the two groups. The total nasal symptom scores, RQLQ and medication scores significantly decreased after immunotherapy in both groups, however no significant differences were noted between the two groups.

Conclusions: We determined that the primary causative allergen of AR in Seoul, Korea is perennial allergens, such as HDMs, rather than seasonal allergens. This study provides a reference for the selection of allergens to use in immunotherapy for polysensitized AR patients living in an urban environment.

No MeSH data available.


Related in: MedlinePlus