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Prevalence of osteoporosis in female patients with advanced knee osteoarthritis undergoing total knee arthroplasty.

Chang CB, Kim TK, Kang YG, Seong SC, Kang SB - J. Korean Med. Sci. (2014)

Bottom Line: BMD conditions in 347 female patients undergoing TKA and 273 community-based females were evaluated.We found no significant differences of the BMD T-scores and the prevalence of osteoporosis between the age and body mass index-matched knee OA and control groups.Our study suggests that more attention should be paid to identify and treat osteoporosis in elderly female patients with advanced knee OA undergoing TKA.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea. ; Department of Orthopedic Surgery SMG-SNU Boramae Medical Center, Seoul, Korea.

ABSTRACT
This study sought to demonstrate bone mineral density (BMD) conditions in elderly female patients with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). In addition, we sought to determine whether their BMD conditions differ from those of community-based females without knee OA. Finally we sought to determine whether clinical statuses are related to BMD in the knee OA patients. BMD conditions in 347 female patients undergoing TKA and 273 community-based females were evaluated. Additionally, comparative analyses of BMD between age and body mass index-matched knee OA groups (n=212) and the control groups (n=212) were performed. In the pre-matched knee OA group, regression analyses were performed to determine whether preoperative clinical statuses were related to BMD. Considerable prevalence of coexistent osteoporosis (31%) was found in the pre-matched knee OA patients undergoing TKA. We found no significant differences of the BMD T-scores and the prevalence of osteoporosis between the age and body mass index-matched knee OA and control groups. In the pre-matched knee OA patients, poorer preoperative clinical scores were related to poorer BMD T-scores in the proximal femur and/or lumbar spine. Our study suggests that more attention should be paid to identify and treat osteoporosis in elderly female patients with advanced knee OA undergoing TKA.

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Related in: MedlinePlus

Study subjects enrollment flowchart. OA, osteoarthritis; TKA, total knee arthroplasty; K/L, Kellgren-Lawrence; BMI, body mass index.
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Figure 1: Study subjects enrollment flowchart. OA, osteoarthritis; TKA, total knee arthroplasty; K/L, Kellgren-Lawrence; BMI, body mass index.

Mentions: For this study, we defined a major study group (knee OA group) which involves elderly female patients with advanced knee OA undergoing TKA. A comparative control group involves community-based elderly female subjects without advanced knee OA. To control the major confounders of BMD and prevalence of osteoporosis between the above two groups, two cohorts were matched for age and body mass index (Fig. 1).


Prevalence of osteoporosis in female patients with advanced knee osteoarthritis undergoing total knee arthroplasty.

Chang CB, Kim TK, Kang YG, Seong SC, Kang SB - J. Korean Med. Sci. (2014)

Study subjects enrollment flowchart. OA, osteoarthritis; TKA, total knee arthroplasty; K/L, Kellgren-Lawrence; BMI, body mass index.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214945&req=5

Figure 1: Study subjects enrollment flowchart. OA, osteoarthritis; TKA, total knee arthroplasty; K/L, Kellgren-Lawrence; BMI, body mass index.
Mentions: For this study, we defined a major study group (knee OA group) which involves elderly female patients with advanced knee OA undergoing TKA. A comparative control group involves community-based elderly female subjects without advanced knee OA. To control the major confounders of BMD and prevalence of osteoporosis between the above two groups, two cohorts were matched for age and body mass index (Fig. 1).

Bottom Line: BMD conditions in 347 female patients undergoing TKA and 273 community-based females were evaluated.We found no significant differences of the BMD T-scores and the prevalence of osteoporosis between the age and body mass index-matched knee OA and control groups.Our study suggests that more attention should be paid to identify and treat osteoporosis in elderly female patients with advanced knee OA undergoing TKA.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea. ; Department of Orthopedic Surgery SMG-SNU Boramae Medical Center, Seoul, Korea.

ABSTRACT
This study sought to demonstrate bone mineral density (BMD) conditions in elderly female patients with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). In addition, we sought to determine whether their BMD conditions differ from those of community-based females without knee OA. Finally we sought to determine whether clinical statuses are related to BMD in the knee OA patients. BMD conditions in 347 female patients undergoing TKA and 273 community-based females were evaluated. Additionally, comparative analyses of BMD between age and body mass index-matched knee OA groups (n=212) and the control groups (n=212) were performed. In the pre-matched knee OA group, regression analyses were performed to determine whether preoperative clinical statuses were related to BMD. Considerable prevalence of coexistent osteoporosis (31%) was found in the pre-matched knee OA patients undergoing TKA. We found no significant differences of the BMD T-scores and the prevalence of osteoporosis between the age and body mass index-matched knee OA and control groups. In the pre-matched knee OA patients, poorer preoperative clinical scores were related to poorer BMD T-scores in the proximal femur and/or lumbar spine. Our study suggests that more attention should be paid to identify and treat osteoporosis in elderly female patients with advanced knee OA undergoing TKA.

Show MeSH
Related in: MedlinePlus