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Association between adipokines and coronary artery lesions in children with Kawasaki Disease.

Kim HJ, Choi EH, Kil HR - J. Korean Med. Sci. (2014)

Bottom Line: In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014).The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively).In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Eulji Universitiy School of Medicine, Daejeon, Korea.

ABSTRACT
Body fat is an important source of adipokine, which is associated with energy balance and inflammatory and immune responses. However, the role of adipokines in coronary artery complications in Kawasaki disease (KD) has not yet been fully explained. We investigated whether serum adipokine level can be a useful marker for patients with KD who are at higher risk of developing coronary artery lesion (CAL). We measured adipokine levels and other inflammatory parameters in 40 patients with KD, 32 febrile controls, and 15 afebrile controls. Interleukin (IL)-6, tumor necrosis factor (TNF)-α and other laboratory parameters were also measured before and after intravenous immunoglobulin therapy, and in the convalescent phase. At admission, the serum resistin levels in KD children were significantly higher than those in controls (177.56 ng/mL in KD children, 76.48 ng/mL in febrile controls, and 17.95 ng/mL in afebrile controls). In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014). The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively). In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.

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Related in: MedlinePlus

Changes in interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels before intravenous immunoglobulin (IVIG) infusion, at 48 hr after IVIG infusion and in the convalescent phase in Kawasaki disease patients.
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Figure 2: Changes in interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels before intravenous immunoglobulin (IVIG) infusion, at 48 hr after IVIG infusion and in the convalescent phase in Kawasaki disease patients.

Mentions: Fig. 1 and Fig. 2 show the changes in serum adipokines, IL-6, and TNF-α levels between the acute stage (before IVIG therapy), 2-4 days after IVIG treatment, and the convalescent phase. The serum adiponectin levels were increased immediately after IVIG therapy but were decreased to baseline levels in the convalescent phase. IL-6 and TNF-α levels peaked at 5.43±1.19 days and 8.0±1.60 days from onset of illness, respectively.


Association between adipokines and coronary artery lesions in children with Kawasaki Disease.

Kim HJ, Choi EH, Kil HR - J. Korean Med. Sci. (2014)

Changes in interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels before intravenous immunoglobulin (IVIG) infusion, at 48 hr after IVIG infusion and in the convalescent phase in Kawasaki disease patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214939&req=5

Figure 2: Changes in interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels before intravenous immunoglobulin (IVIG) infusion, at 48 hr after IVIG infusion and in the convalescent phase in Kawasaki disease patients.
Mentions: Fig. 1 and Fig. 2 show the changes in serum adipokines, IL-6, and TNF-α levels between the acute stage (before IVIG therapy), 2-4 days after IVIG treatment, and the convalescent phase. The serum adiponectin levels were increased immediately after IVIG therapy but were decreased to baseline levels in the convalescent phase. IL-6 and TNF-α levels peaked at 5.43±1.19 days and 8.0±1.60 days from onset of illness, respectively.

Bottom Line: In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014).The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively).In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Eulji Universitiy School of Medicine, Daejeon, Korea.

ABSTRACT
Body fat is an important source of adipokine, which is associated with energy balance and inflammatory and immune responses. However, the role of adipokines in coronary artery complications in Kawasaki disease (KD) has not yet been fully explained. We investigated whether serum adipokine level can be a useful marker for patients with KD who are at higher risk of developing coronary artery lesion (CAL). We measured adipokine levels and other inflammatory parameters in 40 patients with KD, 32 febrile controls, and 15 afebrile controls. Interleukin (IL)-6, tumor necrosis factor (TNF)-α and other laboratory parameters were also measured before and after intravenous immunoglobulin therapy, and in the convalescent phase. At admission, the serum resistin levels in KD children were significantly higher than those in controls (177.56 ng/mL in KD children, 76.48 ng/mL in febrile controls, and 17.95 ng/mL in afebrile controls). In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014). The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively). In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.

Show MeSH
Related in: MedlinePlus