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The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.

Ki Y, Kim W, Cho H, Ahn K, Choi Y, Kim D - J. Korean Med. Sci. (2014)

Bottom Line: Probiotics is reported to have positive effects against radiation-induced enteropathy.There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation.Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

ABSTRACT
Radiation therapy is an important treatment modality for abdominal or pelvic cancer, but there is a common and serious complication such as radiation-induced enteritis. Probiotics is reported to have positive effects against radiation-induced enteropathy. In this study, morphological changes of bowel mucosa were analyzed in rats to presume the effect of probiotics on radiation-induced enteritis and its correlation with radiation dose. A total of 48 adult male Sprague-Dawley rats were randomly assigned to two groups and received a solution containing 1.0×10(8) colony-forming units of Lactiobacillus acidophilus or water once daily for 10 days. Each of two groups was divided into three subgroups and abdomino-pelvic area of each subgroup was irradiated with 10, 15, and 20 Gy, respectively on the seventh day of feeding the solutions. All rats were sacrificed 3 days after irradiation and the mucosal thickness and villus height of jejunum, ileum and colon were measured. The morphological parameters of the small intestine represented significant differences between two solution groups irradiated 10 or 15 Gy, except for villus height of jejunum in 15 Gy-subgroup (P=0.065). There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation. Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.

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Weight loss according radiation dose.
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Figure 1: Weight loss according radiation dose.

Mentions: There were total 3 deaths from diarrhea in the subgroups irradiated with 20 Gy; one rat in L. acidophilus group and two in placebo group. No mortality was observed in the rats irradiated with 10 Gy or 15 Gy in both groups. Statistical comparison to evaluate mortality was not performed because the number of the rats was too small. Mean weight loss of 29 g (range, 23 to 37 g) was observed in the whole rats and, there was no statistically significant difference in weight loss between two groups (P=0.942). The comparison of weight loss by radiation dose between the solution groups is displayed in Fig. 1.


The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.

Ki Y, Kim W, Cho H, Ahn K, Choi Y, Kim D - J. Korean Med. Sci. (2014)

Weight loss according radiation dose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214937&req=5

Figure 1: Weight loss according radiation dose.
Mentions: There were total 3 deaths from diarrhea in the subgroups irradiated with 20 Gy; one rat in L. acidophilus group and two in placebo group. No mortality was observed in the rats irradiated with 10 Gy or 15 Gy in both groups. Statistical comparison to evaluate mortality was not performed because the number of the rats was too small. Mean weight loss of 29 g (range, 23 to 37 g) was observed in the whole rats and, there was no statistically significant difference in weight loss between two groups (P=0.942). The comparison of weight loss by radiation dose between the solution groups is displayed in Fig. 1.

Bottom Line: Probiotics is reported to have positive effects against radiation-induced enteropathy.There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation.Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

ABSTRACT
Radiation therapy is an important treatment modality for abdominal or pelvic cancer, but there is a common and serious complication such as radiation-induced enteritis. Probiotics is reported to have positive effects against radiation-induced enteropathy. In this study, morphological changes of bowel mucosa were analyzed in rats to presume the effect of probiotics on radiation-induced enteritis and its correlation with radiation dose. A total of 48 adult male Sprague-Dawley rats were randomly assigned to two groups and received a solution containing 1.0×10(8) colony-forming units of Lactiobacillus acidophilus or water once daily for 10 days. Each of two groups was divided into three subgroups and abdomino-pelvic area of each subgroup was irradiated with 10, 15, and 20 Gy, respectively on the seventh day of feeding the solutions. All rats were sacrificed 3 days after irradiation and the mucosal thickness and villus height of jejunum, ileum and colon were measured. The morphological parameters of the small intestine represented significant differences between two solution groups irradiated 10 or 15 Gy, except for villus height of jejunum in 15 Gy-subgroup (P=0.065). There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation. Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.

Show MeSH
Related in: MedlinePlus