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Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.

Kang JY, Sung SH, Lee YJ, Choi TI, Choi SJ - J. Korean Med. Sci. (2014)

Bottom Line: In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG.ENPP1 K121Q did not influence the change in IR.However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

View Article: PubMed Central - PubMed

Affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.

ABSTRACT
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

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Related in: MedlinePlus

Association of the change in HOMA-IR and BMI in intervention group with T2DM according to the (A) K allele subjects, (B) Q allele subjects. Δ, Post-Pre; BMI, body mass index; WC, waist circumference; HOMA-IR, homeostasis model of insulin resistance.
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Figure 2: Association of the change in HOMA-IR and BMI in intervention group with T2DM according to the (A) K allele subjects, (B) Q allele subjects. Δ, Post-Pre; BMI, body mass index; WC, waist circumference; HOMA-IR, homeostasis model of insulin resistance.

Mentions: The relationship between HOMA-IR and BMI was analyzed in IG subjects with T2DM (Fig. 2). When assessed across the two genotypes, the positive correlation was highly significant among 97 KK subjects (adjusted β=0.801; P=0.022) and was not significant among the 18 KQ+QQ subjects (adjusted β=-0.521; P=0.428).


Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.

Kang JY, Sung SH, Lee YJ, Choi TI, Choi SJ - J. Korean Med. Sci. (2014)

Association of the change in HOMA-IR and BMI in intervention group with T2DM according to the (A) K allele subjects, (B) Q allele subjects. Δ, Post-Pre; BMI, body mass index; WC, waist circumference; HOMA-IR, homeostasis model of insulin resistance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214934&req=5

Figure 2: Association of the change in HOMA-IR and BMI in intervention group with T2DM according to the (A) K allele subjects, (B) Q allele subjects. Δ, Post-Pre; BMI, body mass index; WC, waist circumference; HOMA-IR, homeostasis model of insulin resistance.
Mentions: The relationship between HOMA-IR and BMI was analyzed in IG subjects with T2DM (Fig. 2). When assessed across the two genotypes, the positive correlation was highly significant among 97 KK subjects (adjusted β=0.801; P=0.022) and was not significant among the 18 KQ+QQ subjects (adjusted β=-0.521; P=0.428).

Bottom Line: In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG.ENPP1 K121Q did not influence the change in IR.However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

View Article: PubMed Central - PubMed

Affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.

ABSTRACT
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

Show MeSH
Related in: MedlinePlus