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Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.

Kang JY, Sung SH, Lee YJ, Choi TI, Choi SJ - J. Korean Med. Sci. (2014)

Bottom Line: In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG.ENPP1 K121Q did not influence the change in IR.However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

View Article: PubMed Central - PubMed

Affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.

ABSTRACT
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

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Flowchart of study participants. FPG, Fasting plasma glucose; T2DM, Type 2 diabetes mellitus.
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Figure 1: Flowchart of study participants. FPG, Fasting plasma glucose; T2DM, Type 2 diabetes mellitus.

Mentions: Flow chart of Participants during the study is shown in Fig. 1. The subjects were recruited from industrial male workers by screening members of the T2DM risk group who participated in annual regular health check-ups in 2010. Exclusion criteria were previously diagnosed T2DM, dyslipidemia, hypertension, cardiovascular disease, and any therapy known to affect glucose and lipid metabolism at basal screening. A total of 477 eligible individuals with newly diabetes (diagnosis of T2DM [fasting plasma glucose (FPG)≥7.0 mM/L] or impaired fasting glucose [IFG] [FPG 5.6-6.9 mM/L]) were called to participate in the web-based lifestyle intervention via e-mail, and 380 individuals accepted the intervention protocol (intervention group [IG]). The control group (CG, n=97) agreed to participate in post-examination, but received no e-mail on healthy lifestyle to improve T2DM. 448 (CG: 82, IG: 366) of 477 individuals who participated in a health follow-up in 2011, were included in the final analyses.


Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.

Kang JY, Sung SH, Lee YJ, Choi TI, Choi SJ - J. Korean Med. Sci. (2014)

Flowchart of study participants. FPG, Fasting plasma glucose; T2DM, Type 2 diabetes mellitus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214934&req=5

Figure 1: Flowchart of study participants. FPG, Fasting plasma glucose; T2DM, Type 2 diabetes mellitus.
Mentions: Flow chart of Participants during the study is shown in Fig. 1. The subjects were recruited from industrial male workers by screening members of the T2DM risk group who participated in annual regular health check-ups in 2010. Exclusion criteria were previously diagnosed T2DM, dyslipidemia, hypertension, cardiovascular disease, and any therapy known to affect glucose and lipid metabolism at basal screening. A total of 477 eligible individuals with newly diabetes (diagnosis of T2DM [fasting plasma glucose (FPG)≥7.0 mM/L] or impaired fasting glucose [IFG] [FPG 5.6-6.9 mM/L]) were called to participate in the web-based lifestyle intervention via e-mail, and 380 individuals accepted the intervention protocol (intervention group [IG]). The control group (CG, n=97) agreed to participate in post-examination, but received no e-mail on healthy lifestyle to improve T2DM. 448 (CG: 82, IG: 366) of 477 individuals who participated in a health follow-up in 2011, were included in the final analyses.

Bottom Line: In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG.ENPP1 K121Q did not influence the change in IR.However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

View Article: PubMed Central - PubMed

Affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.

ABSTRACT
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.

Show MeSH
Related in: MedlinePlus