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Neuropsychological and brain volume differences in patients with left- and right-beginning corticobasal syndrome.

Jütten K, Pieperhoff P, Südmeyer M, Schleicher A, Ferrea S, Caspers S, Zilles K, Schnitzler A, Amunts K, Lux S - PLoS ONE (2014)

Bottom Line: A similar pattern of morphological and neuropsychological differences was found for the individual disease progression in l-CBS and r-CBS single cases.For similar durations of disease, volumetric grey matter loss related to CBS pathology appeared earlier and progressed faster in l-CBS than in r-CBS.Cognitive impairment in r-CBS was characterized by apraxia, and additional memory and perceptional deficits for l-CBS.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.

ABSTRACT

Background: Corticobasal Syndrome (CBS) is a rare neurodegenerative syndrome characterized by unilaterally beginning frontoparietal and basal ganglia atrophy. The study aimed to prove the hypothesis that there are differences in hemispheric susceptibility to disease-related changes.

Methods: Two groups of CBS patients with symptoms starting either on the left or right body side were investigated. Groups consisted of four patients each and were matched for sex, age and disease duration. Patient groups and a group of eight healthy age-matched controls were analyzed using deformation field morphometry and neuropsychological testing. To further characterize individual disease progression regarding brain atrophy and neuropsychological performance, two female, disease duration-matched patients differing in initially impaired body side were followed over six months.

Results: A distinct pattern of neural atrophy and neuropsychological performance was revealed for both CBS: Patients with initial right-sided impairment (r-CBS) revealed atrophy predominantly in frontoparietal areas and showed, except from apraxia, no other cognitive deficits. In contrast, patients with impairment of the left body side (l-CBS) revealed more widespread atrophy, extending from frontoparietal to orbitofrontal and temporal regions; and apraxia, perceptional and memory deficits could be found. A similar pattern of morphological and neuropsychological differences was found for the individual disease progression in l-CBS and r-CBS single cases.

Conclusions: For similar durations of disease, volumetric grey matter loss related to CBS pathology appeared earlier and progressed faster in l-CBS than in r-CBS. Cognitive impairment in r-CBS was characterized by apraxia, and additional memory and perceptional deficits for l-CBS.

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Statistical analysis on brain volumetric differences between l-CBS, r-CBS and healthy controls.a) Two-dimensional canonical analysis of components of significant topographical groups. Euclidean distances were used as measure for differences in local brain volume between CBS groups and controls. b) Results of discriminant analysis and MANOVA.
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pone-0110326-g001: Statistical analysis on brain volumetric differences between l-CBS, r-CBS and healthy controls.a) Two-dimensional canonical analysis of components of significant topographical groups. Euclidean distances were used as measure for differences in local brain volume between CBS groups and controls. b) Results of discriminant analysis and MANOVA.

Mentions: Significant differences were found in local brain volume between l-CBS, r-CBS and controls bilaterally in the frontal cortex, as well as in parietal and temporal regions of the right hemisphere based on results of multivariate statistics on selected principal components of each macroanatomical topography group (Appendix S4). Discriminant analysis revealed that, on the basis of the first two components within each TG, at least 75 percent of the subjects could be classified correctly (Figure 1). With respect to left-hemispheric areal volume, r-CBS patients were best discriminable from l-CBS patients and controls on the basis of PC1 (volume in premotor cortex as most contributing region). In addition, 75 percent of l-CBS patients were differentiable from the control group based on PC2 (volume in orbitofrontal cortex most contributing). Within the right hemisphere, l-CBS patients were perfectly discriminable from r-CBS patients and controls on the basis of regional volume in the superior frontal gyrus. Moreover, l-CBS patients were discriminable from r-CBS patients by volume in the intraparietal sulcus. Both, l-CBS and r-CBS patients were differentiable from the control group by volume in the secondary somatosensory and entorhinal cortex.


Neuropsychological and brain volume differences in patients with left- and right-beginning corticobasal syndrome.

Jütten K, Pieperhoff P, Südmeyer M, Schleicher A, Ferrea S, Caspers S, Zilles K, Schnitzler A, Amunts K, Lux S - PLoS ONE (2014)

Statistical analysis on brain volumetric differences between l-CBS, r-CBS and healthy controls.a) Two-dimensional canonical analysis of components of significant topographical groups. Euclidean distances were used as measure for differences in local brain volume between CBS groups and controls. b) Results of discriminant analysis and MANOVA.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214821&req=5

pone-0110326-g001: Statistical analysis on brain volumetric differences between l-CBS, r-CBS and healthy controls.a) Two-dimensional canonical analysis of components of significant topographical groups. Euclidean distances were used as measure for differences in local brain volume between CBS groups and controls. b) Results of discriminant analysis and MANOVA.
Mentions: Significant differences were found in local brain volume between l-CBS, r-CBS and controls bilaterally in the frontal cortex, as well as in parietal and temporal regions of the right hemisphere based on results of multivariate statistics on selected principal components of each macroanatomical topography group (Appendix S4). Discriminant analysis revealed that, on the basis of the first two components within each TG, at least 75 percent of the subjects could be classified correctly (Figure 1). With respect to left-hemispheric areal volume, r-CBS patients were best discriminable from l-CBS patients and controls on the basis of PC1 (volume in premotor cortex as most contributing region). In addition, 75 percent of l-CBS patients were differentiable from the control group based on PC2 (volume in orbitofrontal cortex most contributing). Within the right hemisphere, l-CBS patients were perfectly discriminable from r-CBS patients and controls on the basis of regional volume in the superior frontal gyrus. Moreover, l-CBS patients were discriminable from r-CBS patients by volume in the intraparietal sulcus. Both, l-CBS and r-CBS patients were differentiable from the control group by volume in the secondary somatosensory and entorhinal cortex.

Bottom Line: A similar pattern of morphological and neuropsychological differences was found for the individual disease progression in l-CBS and r-CBS single cases.For similar durations of disease, volumetric grey matter loss related to CBS pathology appeared earlier and progressed faster in l-CBS than in r-CBS.Cognitive impairment in r-CBS was characterized by apraxia, and additional memory and perceptional deficits for l-CBS.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.

ABSTRACT

Background: Corticobasal Syndrome (CBS) is a rare neurodegenerative syndrome characterized by unilaterally beginning frontoparietal and basal ganglia atrophy. The study aimed to prove the hypothesis that there are differences in hemispheric susceptibility to disease-related changes.

Methods: Two groups of CBS patients with symptoms starting either on the left or right body side were investigated. Groups consisted of four patients each and were matched for sex, age and disease duration. Patient groups and a group of eight healthy age-matched controls were analyzed using deformation field morphometry and neuropsychological testing. To further characterize individual disease progression regarding brain atrophy and neuropsychological performance, two female, disease duration-matched patients differing in initially impaired body side were followed over six months.

Results: A distinct pattern of neural atrophy and neuropsychological performance was revealed for both CBS: Patients with initial right-sided impairment (r-CBS) revealed atrophy predominantly in frontoparietal areas and showed, except from apraxia, no other cognitive deficits. In contrast, patients with impairment of the left body side (l-CBS) revealed more widespread atrophy, extending from frontoparietal to orbitofrontal and temporal regions; and apraxia, perceptional and memory deficits could be found. A similar pattern of morphological and neuropsychological differences was found for the individual disease progression in l-CBS and r-CBS single cases.

Conclusions: For similar durations of disease, volumetric grey matter loss related to CBS pathology appeared earlier and progressed faster in l-CBS than in r-CBS. Cognitive impairment in r-CBS was characterized by apraxia, and additional memory and perceptional deficits for l-CBS.

Show MeSH
Related in: MedlinePlus