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Analysis of human papillomavirus and herpes simplex virus genus -2 from patients with cervical cancer in isfahan, iran.

Shanehsazzadeh M, Sharifi-Rad J, Behbahani M, Pourazar A - Mater Sociomed (2014)

Bottom Line: Although cervical uterine cancer is a second form of cancer among women, but it occupies fifth form among all cancer types.In the present study, human papillomavirus (HPV) and herpes simplex virus 2 (HSV-2) in cervical cancer patients by using real time polymerase chain reaction (PCR) technique and the relation between their viral loads were investigated. 156 cervical carcinoma tissues were collected from married women in health centers in Isfahan, Iran.The results showed that among 156 specimens, 58.97%, 45.51% and 7.05% were positive for HPV DNA, HPV-16 and HPV-18 respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Biology, Zist Partak Institute, Academic Center for Education and Research, Isfahan, Iran.

ABSTRACT

Background: Although cervical uterine cancer is a second form of cancer among women, but it occupies fifth form among all cancer types.

Methods: In the present study, human papillomavirus (HPV) and herpes simplex virus 2 (HSV-2) in cervical cancer patients by using real time polymerase chain reaction (PCR) technique and the relation between their viral loads were investigated. 156 cervical carcinoma tissues were collected from married women in health centers in Isfahan, Iran.

Results: The results showed that among 156 specimens, 58.97%, 45.51% and 7.05% were positive for HPV DNA, HPV-16 and HPV-18 respectively. Only in 2.3% specimens, HSV-2 and HPV-16 were positively detected where viral load HSV-2 in conjunction with HSV-16 dramatically increased.

Conclusion: Thus the present study not only confirmed that viral load of HPV-16 is more than other HPV types, but also in possible conjunction with HSV-2, both rates will significantly increase.

No MeSH data available.


Related in: MedlinePlus

Quantitative data for HPV DNA virus levels. Real-time amplification with fluorescence detection. The plasmid controls for two species, water blank, and negative human control DNA are indicated. The remaining curves are patient specimens with HPV DNA virus levels.
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Figure 2: Quantitative data for HPV DNA virus levels. Real-time amplification with fluorescence detection. The plasmid controls for two species, water blank, and negative human control DNA are indicated. The remaining curves are patient specimens with HPV DNA virus levels.


Analysis of human papillomavirus and herpes simplex virus genus -2 from patients with cervical cancer in isfahan, iran.

Shanehsazzadeh M, Sharifi-Rad J, Behbahani M, Pourazar A - Mater Sociomed (2014)

Quantitative data for HPV DNA virus levels. Real-time amplification with fluorescence detection. The plasmid controls for two species, water blank, and negative human control DNA are indicated. The remaining curves are patient specimens with HPV DNA virus levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214813&req=5

Figure 2: Quantitative data for HPV DNA virus levels. Real-time amplification with fluorescence detection. The plasmid controls for two species, water blank, and negative human control DNA are indicated. The remaining curves are patient specimens with HPV DNA virus levels.
Bottom Line: Although cervical uterine cancer is a second form of cancer among women, but it occupies fifth form among all cancer types.In the present study, human papillomavirus (HPV) and herpes simplex virus 2 (HSV-2) in cervical cancer patients by using real time polymerase chain reaction (PCR) technique and the relation between their viral loads were investigated. 156 cervical carcinoma tissues were collected from married women in health centers in Isfahan, Iran.The results showed that among 156 specimens, 58.97%, 45.51% and 7.05% were positive for HPV DNA, HPV-16 and HPV-18 respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Biology, Zist Partak Institute, Academic Center for Education and Research, Isfahan, Iran.

ABSTRACT

Background: Although cervical uterine cancer is a second form of cancer among women, but it occupies fifth form among all cancer types.

Methods: In the present study, human papillomavirus (HPV) and herpes simplex virus 2 (HSV-2) in cervical cancer patients by using real time polymerase chain reaction (PCR) technique and the relation between their viral loads were investigated. 156 cervical carcinoma tissues were collected from married women in health centers in Isfahan, Iran.

Results: The results showed that among 156 specimens, 58.97%, 45.51% and 7.05% were positive for HPV DNA, HPV-16 and HPV-18 respectively. Only in 2.3% specimens, HSV-2 and HPV-16 were positively detected where viral load HSV-2 in conjunction with HSV-16 dramatically increased.

Conclusion: Thus the present study not only confirmed that viral load of HPV-16 is more than other HPV types, but also in possible conjunction with HSV-2, both rates will significantly increase.

No MeSH data available.


Related in: MedlinePlus