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Erythema at BCG Inoculation Site in Kawasaki Disease Patients.

Rezai MS, Shahmohammadi S - Mater Sociomed (2014)

Bottom Line: A total of 15 articles had been found.Coronary artery abnormalities were found in 10.3% of cases.According to this review, BCGitis is more prevalent than cervical lymphadenopathy and rash and it can be a useful criterion in the diagnosis of incomplete Kawasaki disease in cases not fulfills the classic criteria of at least four of the five findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Antimicrobial Resistant Nosocomial Infectious Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Introduction: Kawasaki disease is an acute, self-limiting childhood systemic vasculitis with unknown etiology. Because there is no diagnostic test for Kawasaki disease, the diagnosis is based on clinical criteria. An important clinical sign that is not included in the classical clinical criteria for Kawasaki disease is a reaction at the Bacille Calmette-Guérin inoculation site that are present in about 30-50% of Kawasaki disease patients.

The aim: of this review was to highlight the usefulness of the inflammation at the Bacille Calmette-Guérin inoculation site for early diagnosis of Kawasaki disease, we conducted a literature review on Medline in PubMed area, Google scholar, Magiran and Scientific Information Database using the search terms "Kawasaki disease, Erythema, BCG, inoculation site, children, cardiac complications, coronary artery lesion, aneurysm, incomplete Kawasaki in 2013.

Results and discussion: A total of 15 articles had been found. Erythema at the Bacille Calmette-Guérin inoculation site was found in 49.87% of Kawasaki disease patients. Coronary artery abnormalities were found in 10.3% of cases. According to this review, BCGitis is more prevalent than cervical lymphadenopathy and rash and it can be a useful criterion in the diagnosis of incomplete Kawasaki disease in cases not fulfills the classic criteria of at least four of the five findings.

No MeSH data available.


Related in: MedlinePlus

Erythema at BCG inoculation site
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Figure 1: Erythema at BCG inoculation site

Mentions: An important clinical sign that is not included in the diagnostic criteria, but can be helpful in the diagnosis of KD is BCGitis or involvement of the BCG scar erythema and induration (Figure 1 910). Acute inflammation at the site of a previous BCG inoculation is one of the unique features of KD among infants in some countries with vaccination policy against tuberculosis (6, 11). BCGitis was reported to have been observed in more than 50% of KD patients 1 to 12 months following BCG inoculation (12). Erythema and induration of a previous BCG vaccination site is a specific and early manifestation of KD (13,14), which was first highlighted in the Japanese literature as a specific and an early sign of KD (15). Several KD cases with BCG reactivation, inflammation, or induration were also reported from other countries (14,16,17).


Erythema at BCG Inoculation Site in Kawasaki Disease Patients.

Rezai MS, Shahmohammadi S - Mater Sociomed (2014)

Erythema at BCG inoculation site
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214810&req=5

Figure 1: Erythema at BCG inoculation site
Mentions: An important clinical sign that is not included in the diagnostic criteria, but can be helpful in the diagnosis of KD is BCGitis or involvement of the BCG scar erythema and induration (Figure 1 910). Acute inflammation at the site of a previous BCG inoculation is one of the unique features of KD among infants in some countries with vaccination policy against tuberculosis (6, 11). BCGitis was reported to have been observed in more than 50% of KD patients 1 to 12 months following BCG inoculation (12). Erythema and induration of a previous BCG vaccination site is a specific and early manifestation of KD (13,14), which was first highlighted in the Japanese literature as a specific and an early sign of KD (15). Several KD cases with BCG reactivation, inflammation, or induration were also reported from other countries (14,16,17).

Bottom Line: A total of 15 articles had been found.Coronary artery abnormalities were found in 10.3% of cases.According to this review, BCGitis is more prevalent than cervical lymphadenopathy and rash and it can be a useful criterion in the diagnosis of incomplete Kawasaki disease in cases not fulfills the classic criteria of at least four of the five findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Antimicrobial Resistant Nosocomial Infectious Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Introduction: Kawasaki disease is an acute, self-limiting childhood systemic vasculitis with unknown etiology. Because there is no diagnostic test for Kawasaki disease, the diagnosis is based on clinical criteria. An important clinical sign that is not included in the classical clinical criteria for Kawasaki disease is a reaction at the Bacille Calmette-Guérin inoculation site that are present in about 30-50% of Kawasaki disease patients.

The aim: of this review was to highlight the usefulness of the inflammation at the Bacille Calmette-Guérin inoculation site for early diagnosis of Kawasaki disease, we conducted a literature review on Medline in PubMed area, Google scholar, Magiran and Scientific Information Database using the search terms "Kawasaki disease, Erythema, BCG, inoculation site, children, cardiac complications, coronary artery lesion, aneurysm, incomplete Kawasaki in 2013.

Results and discussion: A total of 15 articles had been found. Erythema at the Bacille Calmette-Guérin inoculation site was found in 49.87% of Kawasaki disease patients. Coronary artery abnormalities were found in 10.3% of cases. According to this review, BCGitis is more prevalent than cervical lymphadenopathy and rash and it can be a useful criterion in the diagnosis of incomplete Kawasaki disease in cases not fulfills the classic criteria of at least four of the five findings.

No MeSH data available.


Related in: MedlinePlus