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Onward from the cradle.

Satir P - Mol. Biol. Cell (2014)

Bottom Line: This essay records a voyage of discovery from the "cradle of cell biology" to the present, focused on the biology of the oldest known cell organelle, the cilium.In the "romper room" of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born.In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecules cross ciliary necklace barriers for cell signaling.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461 satir@aecom.yu.edu.

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(a) An MEF primary cilium (arrows, inset) labeled in IFM for localization of acetylated α-tubulin (red), 4′,6-diamidino-2-phenylindole (blue), and clathrin (green). (b) SEM and (c and d) CLEM of the same specimen. At the base of the cilium, a ciliary pocket is surrounded by clathrin-coated vesicles. (From J. Kolstrup, Thesis, University of Copenhagen [2012], with permission.)
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Figure 2: (a) An MEF primary cilium (arrows, inset) labeled in IFM for localization of acetylated α-tubulin (red), 4′,6-diamidino-2-phenylindole (blue), and clathrin (green). (b) SEM and (c and d) CLEM of the same specimen. At the base of the cilium, a ciliary pocket is surrounded by clathrin-coated vesicles. (From J. Kolstrup, Thesis, University of Copenhagen [2012], with permission.)


Onward from the cradle.

Satir P - Mol. Biol. Cell (2014)

(a) An MEF primary cilium (arrows, inset) labeled in IFM for localization of acetylated α-tubulin (red), 4′,6-diamidino-2-phenylindole (blue), and clathrin (green). (b) SEM and (c and d) CLEM of the same specimen. At the base of the cilium, a ciliary pocket is surrounded by clathrin-coated vesicles. (From J. Kolstrup, Thesis, University of Copenhagen [2012], with permission.)
© Copyright Policy - creative-commons
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4214774&req=5

Figure 2: (a) An MEF primary cilium (arrows, inset) labeled in IFM for localization of acetylated α-tubulin (red), 4′,6-diamidino-2-phenylindole (blue), and clathrin (green). (b) SEM and (c and d) CLEM of the same specimen. At the base of the cilium, a ciliary pocket is surrounded by clathrin-coated vesicles. (From J. Kolstrup, Thesis, University of Copenhagen [2012], with permission.)
Bottom Line: This essay records a voyage of discovery from the "cradle of cell biology" to the present, focused on the biology of the oldest known cell organelle, the cilium.In the "romper room" of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born.In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecules cross ciliary necklace barriers for cell signaling.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461 satir@aecom.yu.edu.

Show MeSH
Related in: MedlinePlus