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Romancing mitosis and the mitotic apparatus.

Brinkley WB - Mol. Biol. Cell (2014)

Bottom Line: Although first described more than a century ago by early investigators such as E.Building upon those innovations, my laboratory and other contemporary investigators first charted the ultrastructure and molecular organization of mitosis and chromosome movement and the assembly and function of the cytoskeleton.This field of research remains a significant challenge for future investigators in cell biology and medicine.

View Article: PubMed Central - PubMed

Affiliation: Baylor College of Medicine, Molecular and Cellular Biology, Houston, TX 77030 brinkley@bcm.edu.

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Related in: MedlinePlus

Diagram of the kinetochore with associated microtubules and the five compartments within the centromere. Symbols depict centromere-kinetochore proteins that have been identified in various labs. Figure 1a is a crest-stained kinetochore (green) in an Indian M. muntjac chromosome. Figure 1b is an electron micrograph of the kinetochores of an Indian muntjac chromosome. Figure 1c is an image of mammalian chromosomes double stained with crest antibody (green) and antibody to satellite DNA (red). Modified from Brinkley and Slattery (2006).
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Figure 2: Diagram of the kinetochore with associated microtubules and the five compartments within the centromere. Symbols depict centromere-kinetochore proteins that have been identified in various labs. Figure 1a is a crest-stained kinetochore (green) in an Indian M. muntjac chromosome. Figure 1b is an electron micrograph of the kinetochores of an Indian muntjac chromosome. Figure 1c is an image of mammalian chromosomes double stained with crest antibody (green) and antibody to satellite DNA (red). Modified from Brinkley and Slattery (2006).


Romancing mitosis and the mitotic apparatus.

Brinkley WB - Mol. Biol. Cell (2014)

Diagram of the kinetochore with associated microtubules and the five compartments within the centromere. Symbols depict centromere-kinetochore proteins that have been identified in various labs. Figure 1a is a crest-stained kinetochore (green) in an Indian M. muntjac chromosome. Figure 1b is an electron micrograph of the kinetochores of an Indian muntjac chromosome. Figure 1c is an image of mammalian chromosomes double stained with crest antibody (green) and antibody to satellite DNA (red). Modified from Brinkley and Slattery (2006).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4214772&req=5

Figure 2: Diagram of the kinetochore with associated microtubules and the five compartments within the centromere. Symbols depict centromere-kinetochore proteins that have been identified in various labs. Figure 1a is a crest-stained kinetochore (green) in an Indian M. muntjac chromosome. Figure 1b is an electron micrograph of the kinetochores of an Indian muntjac chromosome. Figure 1c is an image of mammalian chromosomes double stained with crest antibody (green) and antibody to satellite DNA (red). Modified from Brinkley and Slattery (2006).
Bottom Line: Although first described more than a century ago by early investigators such as E.Building upon those innovations, my laboratory and other contemporary investigators first charted the ultrastructure and molecular organization of mitosis and chromosome movement and the assembly and function of the cytoskeleton.This field of research remains a significant challenge for future investigators in cell biology and medicine.

View Article: PubMed Central - PubMed

Affiliation: Baylor College of Medicine, Molecular and Cellular Biology, Houston, TX 77030 brinkley@bcm.edu.

Show MeSH
Related in: MedlinePlus