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The microenvironment matters.

Weaver VM - Mol. Biol. Cell (2014)

Bottom Line: The physical and biochemical properties of the microenvironment regulate cell behavior and modulate tissue development and homeostasis.Likewise, the physical and interpersonal cues a trainee receives profoundly influence his or her scientific development, research perspective, and future success.My cell biology career has been greatly impacted by the flavor of the scientific environments I have trained within and the diverse research mentoring I have received.

View Article: PubMed Central - PubMed

Affiliation: Center for Bioengineering and Tissue Regeneration, Department of Surgery, and Departments of Anatomy and Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143 Valerie.Weaver@ucsfmedctr.org.

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Fostering interdisciplinary science. It's not all work and no play. A day out, a bit of sunshine, and liquid refreshments go a long way to nurturing interdisciplinary research. Members of the Center for Bioengineering and Tissue Regeneration on the yearly wine tour. Clockwise from top: Suraj Kachgal (bioengineering postdoc, Boudreau Laboratory), Ori Maller (cell biology postdoc), Jon Lakins (biochemistry lab manager), Matthew Rubashkin (bioengineering graduate student), Janna Mouw (mechanical engineering senior scientist), Matthew Barnes (cell biology postdoc), Christopher Dufort (chemistry postdoc), Jason Tung (bioengineering postdoc), Russell Bainer (genetics postdoc), Laralynne Przybyla (cell biology postdoc), Amanda Wijekoon (cell biology laboratory specialist), Balimkiz Senman (premed student trainee), Laura Damaino (cell biology postdoc), Valerie Weaver (biochemistry principal investigator), and Irene Acerbi (bioengineering postdoc).
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Figure 5: Fostering interdisciplinary science. It's not all work and no play. A day out, a bit of sunshine, and liquid refreshments go a long way to nurturing interdisciplinary research. Members of the Center for Bioengineering and Tissue Regeneration on the yearly wine tour. Clockwise from top: Suraj Kachgal (bioengineering postdoc, Boudreau Laboratory), Ori Maller (cell biology postdoc), Jon Lakins (biochemistry lab manager), Matthew Rubashkin (bioengineering graduate student), Janna Mouw (mechanical engineering senior scientist), Matthew Barnes (cell biology postdoc), Christopher Dufort (chemistry postdoc), Jason Tung (bioengineering postdoc), Russell Bainer (genetics postdoc), Laralynne Przybyla (cell biology postdoc), Amanda Wijekoon (cell biology laboratory specialist), Balimkiz Senman (premed student trainee), Laura Damaino (cell biology postdoc), Valerie Weaver (biochemistry principal investigator), and Irene Acerbi (bioengineering postdoc).

Mentions: Mentoring is one of the privileges and pleasures of being an academic researcher. The joy that I have experienced when one of my students has passed a qualification exam or obtained his or her PhD or when one of my postdoctoral fellows has secured a permanent job and established his or her independence is wonderful. The fun I have interacting with my trainees sustains and nurtures me in multiple ways, and I am constantly learning and being challenged by them (Figure 3). I view the laboratory community I have created as a microcosm of an ideal world in which scientists of all genders, races, and backgrounds and from different disciplines work together to solve key biological questions (Figure 4). Of course, mentoring scientists from different disciplines and team building are not without their challenges, as one struggles with different sensibilities, scientific languages, and perspectives. However, the rewards are many, and I believe that we are united by common goals, including a love of knowledge and an appreciation for the beauty of cell biology and the precision of engineering and the elegance and logic of physics that continue to challenge and motivate us toward the next discovery and the next new concept.


The microenvironment matters.

Weaver VM - Mol. Biol. Cell (2014)

Fostering interdisciplinary science. It's not all work and no play. A day out, a bit of sunshine, and liquid refreshments go a long way to nurturing interdisciplinary research. Members of the Center for Bioengineering and Tissue Regeneration on the yearly wine tour. Clockwise from top: Suraj Kachgal (bioengineering postdoc, Boudreau Laboratory), Ori Maller (cell biology postdoc), Jon Lakins (biochemistry lab manager), Matthew Rubashkin (bioengineering graduate student), Janna Mouw (mechanical engineering senior scientist), Matthew Barnes (cell biology postdoc), Christopher Dufort (chemistry postdoc), Jason Tung (bioengineering postdoc), Russell Bainer (genetics postdoc), Laralynne Przybyla (cell biology postdoc), Amanda Wijekoon (cell biology laboratory specialist), Balimkiz Senman (premed student trainee), Laura Damaino (cell biology postdoc), Valerie Weaver (biochemistry principal investigator), and Irene Acerbi (bioengineering postdoc).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

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Figure 5: Fostering interdisciplinary science. It's not all work and no play. A day out, a bit of sunshine, and liquid refreshments go a long way to nurturing interdisciplinary research. Members of the Center for Bioengineering and Tissue Regeneration on the yearly wine tour. Clockwise from top: Suraj Kachgal (bioengineering postdoc, Boudreau Laboratory), Ori Maller (cell biology postdoc), Jon Lakins (biochemistry lab manager), Matthew Rubashkin (bioengineering graduate student), Janna Mouw (mechanical engineering senior scientist), Matthew Barnes (cell biology postdoc), Christopher Dufort (chemistry postdoc), Jason Tung (bioengineering postdoc), Russell Bainer (genetics postdoc), Laralynne Przybyla (cell biology postdoc), Amanda Wijekoon (cell biology laboratory specialist), Balimkiz Senman (premed student trainee), Laura Damaino (cell biology postdoc), Valerie Weaver (biochemistry principal investigator), and Irene Acerbi (bioengineering postdoc).
Mentions: Mentoring is one of the privileges and pleasures of being an academic researcher. The joy that I have experienced when one of my students has passed a qualification exam or obtained his or her PhD or when one of my postdoctoral fellows has secured a permanent job and established his or her independence is wonderful. The fun I have interacting with my trainees sustains and nurtures me in multiple ways, and I am constantly learning and being challenged by them (Figure 3). I view the laboratory community I have created as a microcosm of an ideal world in which scientists of all genders, races, and backgrounds and from different disciplines work together to solve key biological questions (Figure 4). Of course, mentoring scientists from different disciplines and team building are not without their challenges, as one struggles with different sensibilities, scientific languages, and perspectives. However, the rewards are many, and I believe that we are united by common goals, including a love of knowledge and an appreciation for the beauty of cell biology and the precision of engineering and the elegance and logic of physics that continue to challenge and motivate us toward the next discovery and the next new concept.

Bottom Line: The physical and biochemical properties of the microenvironment regulate cell behavior and modulate tissue development and homeostasis.Likewise, the physical and interpersonal cues a trainee receives profoundly influence his or her scientific development, research perspective, and future success.My cell biology career has been greatly impacted by the flavor of the scientific environments I have trained within and the diverse research mentoring I have received.

View Article: PubMed Central - PubMed

Affiliation: Center for Bioengineering and Tissue Regeneration, Department of Surgery, and Departments of Anatomy and Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143 Valerie.Weaver@ucsfmedctr.org.

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Related in: MedlinePlus