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Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.

Yermalovich MA, Semeiko GV, Samoilovich EO, Svirchevskaya EY, Muller CP, Hübschen JM - PLoS ONE (2014)

Bottom Line: B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years.EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children.HHV6 infection was mostly detected in 6-11 months old infants.

View Article: PubMed Central - PubMed

Affiliation: Republican Research and Practical Center for Epidemiology and Microbiology, Minsk, Belarus.

ABSTRACT
As a result of successful implementation of the measles/rubella elimination program, the etiology of more and more double negative cases remains elusive. The present study determined the role of different viruses as causative agents in measles or rubella suspected cases in Belarus. A total of 856 sera sent to the WHO National Laboratory between 2009 and 2011 were tested for specific IgM antibodies to measles virus (MV), rubella virus (RV) and human parvovirus B19 (B19V). The negatives were further investigated for antibodies to enterovirus (EV) and adenovirus (AdV). Children of up to 3 years were tested for IgM antibodies to human herpesvirus 6 (HHV6). A viral etiology was identified in 451 (52.7%) cases, with 6.1% of the samples being positive for MV; 2.6% for RV; 26.2% for B19V; 9.7% for EV; 4.6% for AdV; and 3.6% for HHV6. Almost all measles and rubella cases occurred during limited outbreaks in 2011 and nearly all patients were at least 15 years old. B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years. B19V occurred mainly in 3-10 years old children and 20-29 years old adults. EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children. HHV6 infection was mostly detected in 6-11 months old infants. Laboratory investigation of measles/rubella suspected cases also for B19V, EV, AdV and HHV6 allows diagnosing more than half of all cases, thus strengthening rash/fever disease surveillance in Belarus.

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Distribution of MV, RV, B19V, EV, AdV and HHV6 IgM positive samples by months, 2009–2011.
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pone-0111541-g003: Distribution of MV, RV, B19V, EV, AdV and HHV6 IgM positive samples by months, 2009–2011.

Mentions: The increase in both measles and rubella incidence was due to limited outbreaks in 2011. Almost all rubella cases (20/22, 90.1%) were reported between January and June 2011 and 94.2% of the measles cases were recorded between May and July 2011 (Figure 3). B19V infections were found throughout the year with peak incidences in March, June and November. Also EV, AdV and HHV6 cases occurred essentially throughout the year (Figure 3).


Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.

Yermalovich MA, Semeiko GV, Samoilovich EO, Svirchevskaya EY, Muller CP, Hübschen JM - PLoS ONE (2014)

Distribution of MV, RV, B19V, EV, AdV and HHV6 IgM positive samples by months, 2009–2011.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214721&req=5

pone-0111541-g003: Distribution of MV, RV, B19V, EV, AdV and HHV6 IgM positive samples by months, 2009–2011.
Mentions: The increase in both measles and rubella incidence was due to limited outbreaks in 2011. Almost all rubella cases (20/22, 90.1%) were reported between January and June 2011 and 94.2% of the measles cases were recorded between May and July 2011 (Figure 3). B19V infections were found throughout the year with peak incidences in March, June and November. Also EV, AdV and HHV6 cases occurred essentially throughout the year (Figure 3).

Bottom Line: B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years.EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children.HHV6 infection was mostly detected in 6-11 months old infants.

View Article: PubMed Central - PubMed

Affiliation: Republican Research and Practical Center for Epidemiology and Microbiology, Minsk, Belarus.

ABSTRACT
As a result of successful implementation of the measles/rubella elimination program, the etiology of more and more double negative cases remains elusive. The present study determined the role of different viruses as causative agents in measles or rubella suspected cases in Belarus. A total of 856 sera sent to the WHO National Laboratory between 2009 and 2011 were tested for specific IgM antibodies to measles virus (MV), rubella virus (RV) and human parvovirus B19 (B19V). The negatives were further investigated for antibodies to enterovirus (EV) and adenovirus (AdV). Children of up to 3 years were tested for IgM antibodies to human herpesvirus 6 (HHV6). A viral etiology was identified in 451 (52.7%) cases, with 6.1% of the samples being positive for MV; 2.6% for RV; 26.2% for B19V; 9.7% for EV; 4.6% for AdV; and 3.6% for HHV6. Almost all measles and rubella cases occurred during limited outbreaks in 2011 and nearly all patients were at least 15 years old. B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years. B19V occurred mainly in 3-10 years old children and 20-29 years old adults. EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children. HHV6 infection was mostly detected in 6-11 months old infants. Laboratory investigation of measles/rubella suspected cases also for B19V, EV, AdV and HHV6 allows diagnosing more than half of all cases, thus strengthening rash/fever disease surveillance in Belarus.

Show MeSH
Related in: MedlinePlus