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Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex.

Matsui Y, Matsubara H, Ueno S, Ito Y, Terasaki H, Kondo M - PLoS ONE (2014)

Bottom Line: Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field.Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact.We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.

ABSTRACT

Purpose: To study the changes in the outer retinal microstructures during a six month period after the onset of acute zonal occult outer retinopathy (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT).

Methods: Seventeen eyes of 17 patients with the AZOOR-complex were studied. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also called the inner/outer segment junction), and interdigitation zone (IDZ; also called the cone outer segment tips) were evaluated in the SD-OCT images obtained at the initial visit and at six months. The three highly reflective bands were divided into three types; continuous, discontinuous, and absent. The integrity of the outer nuclear layer (ONL) was also assessed.

Results: Among the three highly reflective bands, the IDZ was most altered at the initial visit and least recovered at six months. Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field. Three eyes (18%) had retinal areas where the ONL was absent at the initial visit, and there was no recovery in both the retinal structures and visual fields in these areas.

Conclusions: Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact. We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

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Summary of findings of the three highly reflective bands at the outer retina obtained by SD-OCT at the initial visit and six months later.These three lines were divided into three types; “continuous”, “discontinuous” and “absent”. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
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pone-0110592-g006: Summary of findings of the three highly reflective bands at the outer retina obtained by SD-OCT at the initial visit and six months later.These three lines were divided into three types; “continuous”, “discontinuous” and “absent”. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.

Mentions: The changes in the ELM, EZ, and IDZ at the initial visit and six months later are summarized in Figure 6 (see also Table 1). The status of the three highly reflective bands were evaluated at the retinal areas with visual field defects. In this evaluation, we excluded the retinal areas of undetectable ONL, because we noted that the retinal areas with loss of ONL at the initial visit did not show any improvement both in the SD-OCT findings and the visual field defects. Therefore in Figure 6, the results are shown only at the retinal areas of intact ONL.


Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex.

Matsui Y, Matsubara H, Ueno S, Ito Y, Terasaki H, Kondo M - PLoS ONE (2014)

Summary of findings of the three highly reflective bands at the outer retina obtained by SD-OCT at the initial visit and six months later.These three lines were divided into three types; “continuous”, “discontinuous” and “absent”. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214711&req=5

pone-0110592-g006: Summary of findings of the three highly reflective bands at the outer retina obtained by SD-OCT at the initial visit and six months later.These three lines were divided into three types; “continuous”, “discontinuous” and “absent”. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
Mentions: The changes in the ELM, EZ, and IDZ at the initial visit and six months later are summarized in Figure 6 (see also Table 1). The status of the three highly reflective bands were evaluated at the retinal areas with visual field defects. In this evaluation, we excluded the retinal areas of undetectable ONL, because we noted that the retinal areas with loss of ONL at the initial visit did not show any improvement both in the SD-OCT findings and the visual field defects. Therefore in Figure 6, the results are shown only at the retinal areas of intact ONL.

Bottom Line: Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field.Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact.We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.

ABSTRACT

Purpose: To study the changes in the outer retinal microstructures during a six month period after the onset of acute zonal occult outer retinopathy (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT).

Methods: Seventeen eyes of 17 patients with the AZOOR-complex were studied. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also called the inner/outer segment junction), and interdigitation zone (IDZ; also called the cone outer segment tips) were evaluated in the SD-OCT images obtained at the initial visit and at six months. The three highly reflective bands were divided into three types; continuous, discontinuous, and absent. The integrity of the outer nuclear layer (ONL) was also assessed.

Results: Among the three highly reflective bands, the IDZ was most altered at the initial visit and least recovered at six months. Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field. Three eyes (18%) had retinal areas where the ONL was absent at the initial visit, and there was no recovery in both the retinal structures and visual fields in these areas.

Conclusions: Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact. We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

Show MeSH
Related in: MedlinePlus