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Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex.

Matsui Y, Matsubara H, Ueno S, Ito Y, Terasaki H, Kondo M - PLoS ONE (2014)

Bottom Line: Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field.Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact.We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.

ABSTRACT

Purpose: To study the changes in the outer retinal microstructures during a six month period after the onset of acute zonal occult outer retinopathy (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT).

Methods: Seventeen eyes of 17 patients with the AZOOR-complex were studied. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also called the inner/outer segment junction), and interdigitation zone (IDZ; also called the cone outer segment tips) were evaluated in the SD-OCT images obtained at the initial visit and at six months. The three highly reflective bands were divided into three types; continuous, discontinuous, and absent. The integrity of the outer nuclear layer (ONL) was also assessed.

Results: Among the three highly reflective bands, the IDZ was most altered at the initial visit and least recovered at six months. Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field. Three eyes (18%) had retinal areas where the ONL was absent at the initial visit, and there was no recovery in both the retinal structures and visual fields in these areas.

Conclusions: Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact. We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

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Related in: MedlinePlus

Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 3 at the initial visit (A–C) and six months after the initial visit (D–F).A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
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pone-0110592-g005: Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 3 at the initial visit (A–C) and six months after the initial visit (D–F).A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.

Mentions: A 34-year-old myopic woman reported experiencing photophobia and vision reduction of one month duration in her right eye. She had a history of Basedow disease for eight years. Her decimal BCVA was 0.5 OD. Fundus examination and fluorescein angiography were normal, but Humphrey visual field tests revealed a temporal scotoma extending into the fixation point in the right eye (Fig. 5A). The multifocal ERGs were reduced in the centro-temporal field. Based on these clinical findings, she was diagnosed with AZOOR. She was treated with intravenous drip methylprednisolone.


Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex.

Matsui Y, Matsubara H, Ueno S, Ito Y, Terasaki H, Kondo M - PLoS ONE (2014)

Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 3 at the initial visit (A–C) and six months after the initial visit (D–F).A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214711&req=5

pone-0110592-g005: Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 3 at the initial visit (A–C) and six months after the initial visit (D–F).A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
Mentions: A 34-year-old myopic woman reported experiencing photophobia and vision reduction of one month duration in her right eye. She had a history of Basedow disease for eight years. Her decimal BCVA was 0.5 OD. Fundus examination and fluorescein angiography were normal, but Humphrey visual field tests revealed a temporal scotoma extending into the fixation point in the right eye (Fig. 5A). The multifocal ERGs were reduced in the centro-temporal field. Based on these clinical findings, she was diagnosed with AZOOR. She was treated with intravenous drip methylprednisolone.

Bottom Line: Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field.Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact.We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.

ABSTRACT

Purpose: To study the changes in the outer retinal microstructures during a six month period after the onset of acute zonal occult outer retinopathy (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT).

Methods: Seventeen eyes of 17 patients with the AZOOR-complex were studied. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also called the inner/outer segment junction), and interdigitation zone (IDZ; also called the cone outer segment tips) were evaluated in the SD-OCT images obtained at the initial visit and at six months. The three highly reflective bands were divided into three types; continuous, discontinuous, and absent. The integrity of the outer nuclear layer (ONL) was also assessed.

Results: Among the three highly reflective bands, the IDZ was most altered at the initial visit and least recovered at six months. Fifteen of 17 eyes (88%) had a recovery of at least one of the three bands at six months in the retinal area where the ONL was intact, and these areas showed an improvement of visual field. Three eyes (18%) had retinal areas where the ONL was absent at the initial visit, and there was no recovery in both the retinal structures and visual fields in these areas.

Conclusions: Our results indicate that more than 85% eyes with AZOOR-complex show some recovery in the microstructures of the outer retina during a six month period if the ONL is intact. We conclude that SD-OCT is a useful method to monitor the changes of the outer retinal microstructure in eyes with the AZOOR-complex.

Show MeSH
Related in: MedlinePlus