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Relationship of left atrial global peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with non-ST elevation myocardial infarction.

Değirmenci H, Bakırcı EM, Demirtaş L, Duman H, Hamur H, Ceyhun G, Topal E - Med. Sci. Monit. (2014)

Bottom Line: Left atrium peak systolic global longitudinal strain was significantly correlated with left ventricular ejection fraction.There was a significant inverse correlation between left atrium peak systolic global longitudinal strain and brain natriuretic peptide level, left atrium volume maximum, and left atrium volume minimum.Left atrium peak systolic global longitudinal strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Mengücek Gazi Education and Research Hospital, Erzincan University, Erzincan, Turkey.

ABSTRACT

Background: In patients presenting with non-ST elevation myocardial infarction, we investigated the relationship of left atrial deformational parameters evaluated by 2-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and brain natriuretic peptide level.

Material and methods: We enrolled 74 non-ST segment elevation myocardial infarction patients who were treated with percutaneous coronary intervention and 58 healthy control subjects. Non-ST segment elevation myocardial infarction patients had echocardiographic examination 48 h after the percutaneous coronary intervention procedure and venous blood samples were drawn simultaneously. In addition to conventional echocardiographic parameters, left atrial strain curves were obtained for each patient. Average peak left atrial strain values during left ventricular systole were measured.

Results: BNP values were higher in non-ST segment elevation myocardial infarction patients compared to controls. Mean left atrium peak systolic global longitudinal strain in Group 2 (the control group) was higher than in the non-ST segment elevation myocardial infarction group. Left atrium peak systolic global longitudinal strain was significantly correlated with left ventricular ejection fraction. There was a significant inverse correlation between left atrium peak systolic global longitudinal strain and brain natriuretic peptide level, left atrium volume maximum, and left atrium volume minimum.

Conclusions: Our study shows that Left atrium peak systolic global longitudinal strain values decreased consistently with deteriorating systolic and diastolic function in non-ST segment elevation myocardial infarction patients treated with percutaneous coronary intervention. Left atrium peak systolic global longitudinal strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population.

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Related in: MedlinePlus

Correlation of LAGLSs with BNP (LAGLSs: Left atrium global peak systolic strain, BNP: Brain natriuretic peptide).
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f2-medscimonit-20-2013: Correlation of LAGLSs with BNP (LAGLSs: Left atrium global peak systolic strain, BNP: Brain natriuretic peptide).

Mentions: There was a male dominancy in both Group 1 (88.7%) and Group 2 (83%); the mean ages of subjects were 56.4±9.2 years in Group 1 and 54.7±8.4 years in Group 2. Demographic characteristics of Group 1 patients are shown in Table 1. Table 2 shows a comparison of some clinical and echocardiographic characteristics of Group 1 patients and Group 2 individuals. Average time spent for offline analysis of LAGLSs for each patient was 4 min and 94% of LA segments were tracked appropriately by the software and included in our analysis. BNP values were significantly higher in Group 1 patients compared to Group 2 (114 [12.0–1249.5] vs. 6.0 [3.0–23.1]; pg/ml p=0.001). The differences between the measurements of transmitral flow velocities (E, A), and E/Em and E/A ratios of the groups were also significant (Table 2). Maximum and minimum left atrial volumes were increased in Group 1 patients (Table 3). Mean LAGLSs in Group 2 was higher than Group 1 (30.2±5.4% vs. 21.0±6.4% p=0.001). LAGLSs had significant correlation with LVEF (r=0.51, p=0.001), also there was a significant inverse correlation between LAGLSs and BNP level (Figure 2) (r=−0.44, p=0.001), E/Em (r=−0.34, p=0.001), LAVmax (r=−0.43, p=0.001), LAVmin (r=−0.48, p=0.001), LAEF (r=0.36 p=0.001) and LVESV (r=−0.37, p=0.001).


Relationship of left atrial global peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with non-ST elevation myocardial infarction.

Değirmenci H, Bakırcı EM, Demirtaş L, Duman H, Hamur H, Ceyhun G, Topal E - Med. Sci. Monit. (2014)

Correlation of LAGLSs with BNP (LAGLSs: Left atrium global peak systolic strain, BNP: Brain natriuretic peptide).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4214700&req=5

f2-medscimonit-20-2013: Correlation of LAGLSs with BNP (LAGLSs: Left atrium global peak systolic strain, BNP: Brain natriuretic peptide).
Mentions: There was a male dominancy in both Group 1 (88.7%) and Group 2 (83%); the mean ages of subjects were 56.4±9.2 years in Group 1 and 54.7±8.4 years in Group 2. Demographic characteristics of Group 1 patients are shown in Table 1. Table 2 shows a comparison of some clinical and echocardiographic characteristics of Group 1 patients and Group 2 individuals. Average time spent for offline analysis of LAGLSs for each patient was 4 min and 94% of LA segments were tracked appropriately by the software and included in our analysis. BNP values were significantly higher in Group 1 patients compared to Group 2 (114 [12.0–1249.5] vs. 6.0 [3.0–23.1]; pg/ml p=0.001). The differences between the measurements of transmitral flow velocities (E, A), and E/Em and E/A ratios of the groups were also significant (Table 2). Maximum and minimum left atrial volumes were increased in Group 1 patients (Table 3). Mean LAGLSs in Group 2 was higher than Group 1 (30.2±5.4% vs. 21.0±6.4% p=0.001). LAGLSs had significant correlation with LVEF (r=0.51, p=0.001), also there was a significant inverse correlation between LAGLSs and BNP level (Figure 2) (r=−0.44, p=0.001), E/Em (r=−0.34, p=0.001), LAVmax (r=−0.43, p=0.001), LAVmin (r=−0.48, p=0.001), LAEF (r=0.36 p=0.001) and LVESV (r=−0.37, p=0.001).

Bottom Line: Left atrium peak systolic global longitudinal strain was significantly correlated with left ventricular ejection fraction.There was a significant inverse correlation between left atrium peak systolic global longitudinal strain and brain natriuretic peptide level, left atrium volume maximum, and left atrium volume minimum.Left atrium peak systolic global longitudinal strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Mengücek Gazi Education and Research Hospital, Erzincan University, Erzincan, Turkey.

ABSTRACT

Background: In patients presenting with non-ST elevation myocardial infarction, we investigated the relationship of left atrial deformational parameters evaluated by 2-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and brain natriuretic peptide level.

Material and methods: We enrolled 74 non-ST segment elevation myocardial infarction patients who were treated with percutaneous coronary intervention and 58 healthy control subjects. Non-ST segment elevation myocardial infarction patients had echocardiographic examination 48 h after the percutaneous coronary intervention procedure and venous blood samples were drawn simultaneously. In addition to conventional echocardiographic parameters, left atrial strain curves were obtained for each patient. Average peak left atrial strain values during left ventricular systole were measured.

Results: BNP values were higher in non-ST segment elevation myocardial infarction patients compared to controls. Mean left atrium peak systolic global longitudinal strain in Group 2 (the control group) was higher than in the non-ST segment elevation myocardial infarction group. Left atrium peak systolic global longitudinal strain was significantly correlated with left ventricular ejection fraction. There was a significant inverse correlation between left atrium peak systolic global longitudinal strain and brain natriuretic peptide level, left atrium volume maximum, and left atrium volume minimum.

Conclusions: Our study shows that Left atrium peak systolic global longitudinal strain values decreased consistently with deteriorating systolic and diastolic function in non-ST segment elevation myocardial infarction patients treated with percutaneous coronary intervention. Left atrium peak systolic global longitudinal strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population.

Show MeSH
Related in: MedlinePlus