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Spatial analysis on hepatitis C virus infection in mainland China: from 2005 to 2011.

Wang L, Xing J, Chen F, Yan R, Ge L, Qin Q, Wang L, Ding Z, Guo W, Wang N - PLoS ONE (2014)

Bottom Line: Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China.Tibet, Qinghai, Jiangxi were the regions that had coldspots.Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.

View Article: PubMed Central - PubMed

Affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

ABSTRACT

Background: The burden of Hepatitis C virus (HCV) has become more and more considerable in China. A macroscopic spatial analysis of HCV infection that can provide scientific information for further intervention and disease control is lacking.

Methods: All geo-referenced HCV cases that had been recorded by the China Information System for Disease Control and Prevention (CISDCP) during 2005-2011 were included in the study. In order to learn about the changes of demographic characteristics and geographic distribution, trend test and spatial analysis were conducted to reflect the changing pattern of HCV infection.

Results: Over 770,000 identified HCV infection cases had specific geographic information during the study period (2005-2011). Ratios of gender (Male/Female, Z-value  = -18.53, P<0.001), age group (≤30 years old/≥31 years old, Z-value  = -51.03, P<0.001) and diagnosis type (Clinical diagnosis/Laboratory diagnosis, Z-value  = -130.47, P<0.001) declined. HCV infection was not distributed randomly. Provinces Henan, Guangdong, Guangxi, Xinjiang, and Jilin reported more than 40,000 HCV infections during 2005 to 2011, accounting for 43.91% of all cases. The strength of cluster of disease was increasing in China during the study period. Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China. Tibet, Qinghai, Jiangxi were the regions that had coldspots.

Conclusions: The number of clustering of HCV infection among older adults increased in recent years. Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.

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Related in: MedlinePlus

(A) Number and Moran's Index of identified HCV infection cases by year. (B) Ratio of gender, age group and diagnosis type of identified HCV infection cases by year.
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pone-0110861-g001: (A) Number and Moran's Index of identified HCV infection cases by year. (B) Ratio of gender, age group and diagnosis type of identified HCV infection cases by year.

Mentions: There were774,787 identified HCV infection cases that had accurate geographic information during the study period (2005–2011).7,568 cases(accounting for 0.98% of all identified) were excluded from the present study, due to lack of spatial information. Increased trend of number of identified HCV infection cases with years was observed (Figure 1A). During 2005–2011, the overall gender ratio (male/female) was 1.39; the mean age of all cases was 47.31 years (95%CI: 47.27 to 47.35) and, 16.51% of cases were ≤30 years. Almost 83.8%of HCV infection cases were identified by laboratory diagnosis and the rest were identified by clinical diagnosis.


Spatial analysis on hepatitis C virus infection in mainland China: from 2005 to 2011.

Wang L, Xing J, Chen F, Yan R, Ge L, Qin Q, Wang L, Ding Z, Guo W, Wang N - PLoS ONE (2014)

(A) Number and Moran's Index of identified HCV infection cases by year. (B) Ratio of gender, age group and diagnosis type of identified HCV infection cases by year.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214689&req=5

pone-0110861-g001: (A) Number and Moran's Index of identified HCV infection cases by year. (B) Ratio of gender, age group and diagnosis type of identified HCV infection cases by year.
Mentions: There were774,787 identified HCV infection cases that had accurate geographic information during the study period (2005–2011).7,568 cases(accounting for 0.98% of all identified) were excluded from the present study, due to lack of spatial information. Increased trend of number of identified HCV infection cases with years was observed (Figure 1A). During 2005–2011, the overall gender ratio (male/female) was 1.39; the mean age of all cases was 47.31 years (95%CI: 47.27 to 47.35) and, 16.51% of cases were ≤30 years. Almost 83.8%of HCV infection cases were identified by laboratory diagnosis and the rest were identified by clinical diagnosis.

Bottom Line: Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China.Tibet, Qinghai, Jiangxi were the regions that had coldspots.Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.

View Article: PubMed Central - PubMed

Affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

ABSTRACT

Background: The burden of Hepatitis C virus (HCV) has become more and more considerable in China. A macroscopic spatial analysis of HCV infection that can provide scientific information for further intervention and disease control is lacking.

Methods: All geo-referenced HCV cases that had been recorded by the China Information System for Disease Control and Prevention (CISDCP) during 2005-2011 were included in the study. In order to learn about the changes of demographic characteristics and geographic distribution, trend test and spatial analysis were conducted to reflect the changing pattern of HCV infection.

Results: Over 770,000 identified HCV infection cases had specific geographic information during the study period (2005-2011). Ratios of gender (Male/Female, Z-value  = -18.53, P<0.001), age group (≤30 years old/≥31 years old, Z-value  = -51.03, P<0.001) and diagnosis type (Clinical diagnosis/Laboratory diagnosis, Z-value  = -130.47, P<0.001) declined. HCV infection was not distributed randomly. Provinces Henan, Guangdong, Guangxi, Xinjiang, and Jilin reported more than 40,000 HCV infections during 2005 to 2011, accounting for 43.91% of all cases. The strength of cluster of disease was increasing in China during the study period. Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China. Tibet, Qinghai, Jiangxi were the regions that had coldspots.

Conclusions: The number of clustering of HCV infection among older adults increased in recent years. Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.

Show MeSH
Related in: MedlinePlus