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Separation of hepatic iron and fat by dual-source dual-energy computed tomography based on material decomposition: an animal study.

Ma J, Song ZQ, Yan FH - PLoS ONE (2014)

Bottom Line: Spearman's correlation and one-way analysis of variance (ANOVA) were performed, respectively, to analyze statistically the correlations with the histopathological results and differences among groups.Different groups showed significantly different iron enhancement values and VNC values (F = 25.308,p<0.001; F = 10.911, p<0.001, respectively).Among the groups, significant differences in iron enhancement values were only observed between the iron-present and iron-absent groups, and differences in VNC values were only observed between the fat-present and fat-absent groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Shanghai Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Department of Radiology, the 2nd Affiliated Hospital of Shi-Hezi University Medical School (Corps Hospital), Urumqi, Xinjiang Province, China.

ABSTRACT

Objective: To explore the feasibility of dual-source dual-energy computed tomography (DSDECT) for hepatic iron and fat separation in vivo.

Materials and methods: All of the procedures in this study were approved by the Research Animal Resource Center of Shanghai Ruijin Hospital. Sixty rats that underwent DECT scanning were divided into the normal group, fatty liver group, liver iron group, and coexisting liver iron and fat group, according to Prussian blue and HE staining. The data for each group were reconstructed and post-processed by an iron-specific, three-material decomposition algorithm. The iron enhancement value and the virtual non-iron contrast value, which indicated overloaded liver iron and residual liver tissue, respectively, were measured. Spearman's correlation and one-way analysis of variance (ANOVA) were performed, respectively, to analyze statistically the correlations with the histopathological results and differences among groups.

Results: The iron enhancement values were positively correlated with the iron pathology grading (r = 0.729, p<0.001). Virtual non-iron contrast (VNC) values were negatively correlated with the fat pathology grading (r = -0.642,p<0.0001). Different groups showed significantly different iron enhancement values and VNC values (F = 25.308,p<0.001; F = 10.911, p<0.001, respectively). Among the groups, significant differences in iron enhancement values were only observed between the iron-present and iron-absent groups, and differences in VNC values were only observed between the fat-present and fat-absent groups.

Conclusion: Separation of hepatic iron and fat by dual energy material decomposition in vivo was feasible, even when they coexisted.

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Related in: MedlinePlus

VNC values for the four groups were significantly different among the groups (F = 10.911,p<0.001).The VNC values for the steatosis-present groups were smaller than those for steatosis-absent groups.
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pone-0110964-g006: VNC values for the four groups were significantly different among the groups (F = 10.911,p<0.001).The VNC values for the steatosis-present groups were smaller than those for steatosis-absent groups.

Mentions: The VNC values were also significantly different among the groups (F = 10.911, p<0.001) (Figure 6). The VNC values for the steatosis-present groups were smaller than for the steatosis-absent groups. The following significant differences were observed: normal group vs fatty liver group (p = 0.035), normal group vs coexisting group (p = 0.01), fatty liver group vs liver iron group (p<0.001), and coexisting group vs liver iron group (p<0.001).


Separation of hepatic iron and fat by dual-source dual-energy computed tomography based on material decomposition: an animal study.

Ma J, Song ZQ, Yan FH - PLoS ONE (2014)

VNC values for the four groups were significantly different among the groups (F = 10.911,p<0.001).The VNC values for the steatosis-present groups were smaller than those for steatosis-absent groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214685&req=5

pone-0110964-g006: VNC values for the four groups were significantly different among the groups (F = 10.911,p<0.001).The VNC values for the steatosis-present groups were smaller than those for steatosis-absent groups.
Mentions: The VNC values were also significantly different among the groups (F = 10.911, p<0.001) (Figure 6). The VNC values for the steatosis-present groups were smaller than for the steatosis-absent groups. The following significant differences were observed: normal group vs fatty liver group (p = 0.035), normal group vs coexisting group (p = 0.01), fatty liver group vs liver iron group (p<0.001), and coexisting group vs liver iron group (p<0.001).

Bottom Line: Spearman's correlation and one-way analysis of variance (ANOVA) were performed, respectively, to analyze statistically the correlations with the histopathological results and differences among groups.Different groups showed significantly different iron enhancement values and VNC values (F = 25.308,p<0.001; F = 10.911, p<0.001, respectively).Among the groups, significant differences in iron enhancement values were only observed between the iron-present and iron-absent groups, and differences in VNC values were only observed between the fat-present and fat-absent groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Shanghai Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Department of Radiology, the 2nd Affiliated Hospital of Shi-Hezi University Medical School (Corps Hospital), Urumqi, Xinjiang Province, China.

ABSTRACT

Objective: To explore the feasibility of dual-source dual-energy computed tomography (DSDECT) for hepatic iron and fat separation in vivo.

Materials and methods: All of the procedures in this study were approved by the Research Animal Resource Center of Shanghai Ruijin Hospital. Sixty rats that underwent DECT scanning were divided into the normal group, fatty liver group, liver iron group, and coexisting liver iron and fat group, according to Prussian blue and HE staining. The data for each group were reconstructed and post-processed by an iron-specific, three-material decomposition algorithm. The iron enhancement value and the virtual non-iron contrast value, which indicated overloaded liver iron and residual liver tissue, respectively, were measured. Spearman's correlation and one-way analysis of variance (ANOVA) were performed, respectively, to analyze statistically the correlations with the histopathological results and differences among groups.

Results: The iron enhancement values were positively correlated with the iron pathology grading (r = 0.729, p<0.001). Virtual non-iron contrast (VNC) values were negatively correlated with the fat pathology grading (r = -0.642,p<0.0001). Different groups showed significantly different iron enhancement values and VNC values (F = 25.308,p<0.001; F = 10.911, p<0.001, respectively). Among the groups, significant differences in iron enhancement values were only observed between the iron-present and iron-absent groups, and differences in VNC values were only observed between the fat-present and fat-absent groups.

Conclusion: Separation of hepatic iron and fat by dual energy material decomposition in vivo was feasible, even when they coexisted.

Show MeSH
Related in: MedlinePlus