Limits...
Minimal deviation mucinous adenocarcinoma of the uterine cervix that proved difficult to differentiate from endometrial cancer: A case report.

Nishii Y, Fukuda T, Imai K, Yamauchi M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T - Oncol Lett (2014)

Bottom Line: Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas.Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870.The patient is currently alive with the disease 10 months following the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

ABSTRACT
Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas. Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870. Using magnetic resonance imaging (MRI), MDA appears as multilocular lesions with solid components that extend from the endocervical glands to the deep cervical stroma. Cytological evaluation and biopsies have low detection rates, therefore, it is difficult to diagnose MDA accurately prior to treatment. The current study describes a rare case of MDA that was difficult to differentiate from endometrial adenocarcinoma of the corpus uteri preoperatively, as the endometrial biopsy results suggested a well-differentiated endometrioid adenocarcinoma and MRI did not show typical images for MDA. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed under the diagnosis of endometrial cancer, and the mass was subsequently diagnosed as MDA of the uterine cervix by pathological examination of the hysterectomy specimen. Postoperatively, although two types of adjuvant chemotherapy were performed, the remaining tumor continued to grow, causing obstruction of the bilateral ureters and leading to bilateral hydronephrosis. The patient is currently alive with the disease 10 months following the surgery.

No MeSH data available.


Related in: MedlinePlus

(A) Low-power and (B) high-power view of minimal deviation adenocarcinoma histopathology. The glands are well-differentiated and show minimal cytological atypia. The density of glands is increased and a number of glands are back to back [magnification, (A) ×20 and (B) ×200.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4214510&req=5

f1-ol-08-06-2481: (A) Low-power and (B) high-power view of minimal deviation adenocarcinoma histopathology. The glands are well-differentiated and show minimal cytological atypia. The density of glands is increased and a number of glands are back to back [magnification, (A) ×20 and (B) ×200.]

Mentions: On presentation, the patient exhibited a small volume of bloody vaginal discharge. The uterine corpus was enlarged to 85 mm in size and the uterine cervix was not enlarged or abnormal. Transvaginal ultrasonography revealed a small amount of ascites and mildly thickened endometrium. The fallopian tubes and ovaries exhibited no abnormalities. A cervical smear was negative for intraepithelial lesions or malignancy and an endometrial biopsy revealed a well-differentiated suspected endometrioid adenocarcinoma (Fig. 1). magnetic resonance imaging (MRI) revealed mucus retention in the endometrial cavity and multiple cysts from the uterine corpus to the uterine cervix, with low intensity on T1-weighted images and high intensity on T2-weighted images. No enlargement of the uterine cervix was observed. T2-weighted images revealed a high-intensity area in the endometrium of the uterine corpus (Fig. 2). A chest CT revealed the enlargement of the supraclavicular lymph nodes. Serum carbohydrate antigen (CA)-125 levels were 153 U/ml (normal, <35 U/ml) and CA19-9 levels were 44 U/ml (normal, <37 U/ml), while carcinoembryonic antigen and sialyl-Tn antigen levels were within the normal ranges.


Minimal deviation mucinous adenocarcinoma of the uterine cervix that proved difficult to differentiate from endometrial cancer: A case report.

Nishii Y, Fukuda T, Imai K, Yamauchi M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T - Oncol Lett (2014)

(A) Low-power and (B) high-power view of minimal deviation adenocarcinoma histopathology. The glands are well-differentiated and show minimal cytological atypia. The density of glands is increased and a number of glands are back to back [magnification, (A) ×20 and (B) ×200.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214510&req=5

f1-ol-08-06-2481: (A) Low-power and (B) high-power view of minimal deviation adenocarcinoma histopathology. The glands are well-differentiated and show minimal cytological atypia. The density of glands is increased and a number of glands are back to back [magnification, (A) ×20 and (B) ×200.]
Mentions: On presentation, the patient exhibited a small volume of bloody vaginal discharge. The uterine corpus was enlarged to 85 mm in size and the uterine cervix was not enlarged or abnormal. Transvaginal ultrasonography revealed a small amount of ascites and mildly thickened endometrium. The fallopian tubes and ovaries exhibited no abnormalities. A cervical smear was negative for intraepithelial lesions or malignancy and an endometrial biopsy revealed a well-differentiated suspected endometrioid adenocarcinoma (Fig. 1). magnetic resonance imaging (MRI) revealed mucus retention in the endometrial cavity and multiple cysts from the uterine corpus to the uterine cervix, with low intensity on T1-weighted images and high intensity on T2-weighted images. No enlargement of the uterine cervix was observed. T2-weighted images revealed a high-intensity area in the endometrium of the uterine corpus (Fig. 2). A chest CT revealed the enlargement of the supraclavicular lymph nodes. Serum carbohydrate antigen (CA)-125 levels were 153 U/ml (normal, <35 U/ml) and CA19-9 levels were 44 U/ml (normal, <37 U/ml), while carcinoembryonic antigen and sialyl-Tn antigen levels were within the normal ranges.

Bottom Line: Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas.Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870.The patient is currently alive with the disease 10 months following the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

ABSTRACT
Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas. Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870. Using magnetic resonance imaging (MRI), MDA appears as multilocular lesions with solid components that extend from the endocervical glands to the deep cervical stroma. Cytological evaluation and biopsies have low detection rates, therefore, it is difficult to diagnose MDA accurately prior to treatment. The current study describes a rare case of MDA that was difficult to differentiate from endometrial adenocarcinoma of the corpus uteri preoperatively, as the endometrial biopsy results suggested a well-differentiated endometrioid adenocarcinoma and MRI did not show typical images for MDA. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed under the diagnosis of endometrial cancer, and the mass was subsequently diagnosed as MDA of the uterine cervix by pathological examination of the hysterectomy specimen. Postoperatively, although two types of adjuvant chemotherapy were performed, the remaining tumor continued to grow, causing obstruction of the bilateral ureters and leading to bilateral hydronephrosis. The patient is currently alive with the disease 10 months following the surgery.

No MeSH data available.


Related in: MedlinePlus