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Bone marrow metastasis of colon cancer as the first site of recurrence: A case report.

Lim DH, Lee SI, Park KW - Oncol Lett (2014)

Bottom Line: There was no evidence of skeletal metastasis.The clinical course was extremely aggressive and the patient succumbed ten days after admission, finally being diagnosed in the postmortem examination.The present study also discusses bone marrow metastasis of solid tumors, with particular respect to the diagnostic difficulties of such rare cases.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology-Oncology, Department of Medicine, Dankook University College of Medicine, Cheonan, South Chungcheong 330-715, Republic of Korea.

ABSTRACT
Bone marrow metastasis from solid tumors is usually accepted as not only incurable, but as fatal. Colon cancer is a relatively rare malignancy that involves the bone marrow, and to the best of our knowledge, there have been no studies in the literature reporting only bone marrow metastasis of colon cancer as the first presentation of relapse. The present study reports the case of a 74-year-old female patient treated by resection and adjuvant chemotherapy for stage IIIc colon cancer who presented with severe thrombocytopenia with intracranial hemorrhage, and the bone marrow was first and only site of metastasis. There was no evidence of skeletal metastasis. The clinical course was extremely aggressive and the patient succumbed ten days after admission, finally being diagnosed in the postmortem examination. The present study also discusses bone marrow metastasis of solid tumors, with particular respect to the diagnostic difficulties of such rare cases.

No MeSH data available.


Related in: MedlinePlus

Biopsy specimen showing poorly-differentiated adenocarcinoma with signet ring cell features in the cecum (hematoxylin and eosin; magnification, ×200).
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f1-ol-08-06-2672: Biopsy specimen showing poorly-differentiated adenocarcinoma with signet ring cell features in the cecum (hematoxylin and eosin; magnification, ×200).

Mentions: A 74-year-old female patient visited the Department of Hematology-Oncology, Dankook University of Medicine (Cheonan, Korea) for the evaluation and treatment of thrombocytopenia and an increased bleeding tendency. The patient had previously undergone a right hemicolectomy with ileocolostomy due to colon cancer three years previously. At that time, the obtained surgical specimen was diagnosed as adenocarcinoma, with signet ring cell features (Fig. 1), and the surgical staging was pT3N2M0, stage IIIc. The patient received adjuvant chemotherapy with oxaliplatin (85 mg/m2, day 1), leucovorin (200 mg/m2, days 1 and 2) and 5-fluorouracil (400 mg/m2 i.v. bolus and subsequently 600 mg/m2 i.v. continuously for 22 h, days 1–2) every two weeks for six months. Subsequent to this, the patient was followed up regularly and there was no evidence of disease recurrence until the last abdominopelvic computed tomography (CT) scans, 50 days prior to the current admission.


Bone marrow metastasis of colon cancer as the first site of recurrence: A case report.

Lim DH, Lee SI, Park KW - Oncol Lett (2014)

Biopsy specimen showing poorly-differentiated adenocarcinoma with signet ring cell features in the cecum (hematoxylin and eosin; magnification, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214508&req=5

f1-ol-08-06-2672: Biopsy specimen showing poorly-differentiated adenocarcinoma with signet ring cell features in the cecum (hematoxylin and eosin; magnification, ×200).
Mentions: A 74-year-old female patient visited the Department of Hematology-Oncology, Dankook University of Medicine (Cheonan, Korea) for the evaluation and treatment of thrombocytopenia and an increased bleeding tendency. The patient had previously undergone a right hemicolectomy with ileocolostomy due to colon cancer three years previously. At that time, the obtained surgical specimen was diagnosed as adenocarcinoma, with signet ring cell features (Fig. 1), and the surgical staging was pT3N2M0, stage IIIc. The patient received adjuvant chemotherapy with oxaliplatin (85 mg/m2, day 1), leucovorin (200 mg/m2, days 1 and 2) and 5-fluorouracil (400 mg/m2 i.v. bolus and subsequently 600 mg/m2 i.v. continuously for 22 h, days 1–2) every two weeks for six months. Subsequent to this, the patient was followed up regularly and there was no evidence of disease recurrence until the last abdominopelvic computed tomography (CT) scans, 50 days prior to the current admission.

Bottom Line: There was no evidence of skeletal metastasis.The clinical course was extremely aggressive and the patient succumbed ten days after admission, finally being diagnosed in the postmortem examination.The present study also discusses bone marrow metastasis of solid tumors, with particular respect to the diagnostic difficulties of such rare cases.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology-Oncology, Department of Medicine, Dankook University College of Medicine, Cheonan, South Chungcheong 330-715, Republic of Korea.

ABSTRACT
Bone marrow metastasis from solid tumors is usually accepted as not only incurable, but as fatal. Colon cancer is a relatively rare malignancy that involves the bone marrow, and to the best of our knowledge, there have been no studies in the literature reporting only bone marrow metastasis of colon cancer as the first presentation of relapse. The present study reports the case of a 74-year-old female patient treated by resection and adjuvant chemotherapy for stage IIIc colon cancer who presented with severe thrombocytopenia with intracranial hemorrhage, and the bone marrow was first and only site of metastasis. There was no evidence of skeletal metastasis. The clinical course was extremely aggressive and the patient succumbed ten days after admission, finally being diagnosed in the postmortem examination. The present study also discusses bone marrow metastasis of solid tumors, with particular respect to the diagnostic difficulties of such rare cases.

No MeSH data available.


Related in: MedlinePlus