Limits...
Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus

NKG2D expression in the blood. NKG2D, natural killer group 2 member D; GTN, glyceryl trinitrate. *P<0.001 vs. GTN and placebo group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4214498&req=5

f8-ol-08-06-2371: NKG2D expression in the blood. NKG2D, natural killer group 2 member D; GTN, glyceryl trinitrate. *P<0.001 vs. GTN and placebo group.

Mentions: Blood samples were collected from the two groups to analyze the levels of NKG2D. Flow cytometry revealed that the GTN and normal groups exhibited significantly higher levels of NKG2D when compared with the placebo group (Figs. 8 and 9; Table VIII). In addition, NKG2D and sMIC were found to be negatively correlated (data not shown).


Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

NKG2D expression in the blood. NKG2D, natural killer group 2 member D; GTN, glyceryl trinitrate. *P<0.001 vs. GTN and placebo group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214498&req=5

f8-ol-08-06-2371: NKG2D expression in the blood. NKG2D, natural killer group 2 member D; GTN, glyceryl trinitrate. *P<0.001 vs. GTN and placebo group.
Mentions: Blood samples were collected from the two groups to analyze the levels of NKG2D. Flow cytometry revealed that the GTN and normal groups exhibited significantly higher levels of NKG2D when compared with the placebo group (Figs. 8 and 9; Table VIII). In addition, NKG2D and sMIC were found to be negatively correlated (data not shown).

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus