Limits...
Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus

Expression of sMIC in serum.*P<0.001 vs. normal and GTN group. **P<0.001 vs. normal and GTN group. GTN, glyceryl trinitrate; sMIC, soluble major histocompatibility complex class I chain-related.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4214498&req=5

f7-ol-08-06-2371: Expression of sMIC in serum.*P<0.001 vs. normal and GTN group. **P<0.001 vs. normal and GTN group. GTN, glyceryl trinitrate; sMIC, soluble major histocompatibility complex class I chain-related.

Mentions: As noted above, the same mRNA levels, but different protein levels of MIC A/B were identified between the two groups. To assess whether cellular MIC was transferred outside of the membrane, the levels of sMIC in serum were investigated. ELISA revealed that the placebo group exhibited higher levels of sMIC than the GTN group and the two groups exhibited significantly higher sMIC levels when compared with those of the normal mice (Fig. 7 and Table VII).


Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Expression of sMIC in serum.*P<0.001 vs. normal and GTN group. **P<0.001 vs. normal and GTN group. GTN, glyceryl trinitrate; sMIC, soluble major histocompatibility complex class I chain-related.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214498&req=5

f7-ol-08-06-2371: Expression of sMIC in serum.*P<0.001 vs. normal and GTN group. **P<0.001 vs. normal and GTN group. GTN, glyceryl trinitrate; sMIC, soluble major histocompatibility complex class I chain-related.
Mentions: As noted above, the same mRNA levels, but different protein levels of MIC A/B were identified between the two groups. To assess whether cellular MIC was transferred outside of the membrane, the levels of sMIC in serum were investigated. ELISA revealed that the placebo group exhibited higher levels of sMIC than the GTN group and the two groups exhibited significantly higher sMIC levels when compared with those of the normal mice (Fig. 7 and Table VII).

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus