Limits...
Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus

Relative expression of MIC A/B mRNA in tumors. MIC A/B, major histocompatibility class I-related chain A/B; GTN, glyceryl trinitrate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4214498&req=5

f5-ol-08-06-2371: Relative expression of MIC A/B mRNA in tumors. MIC A/B, major histocompatibility class I-related chain A/B; GTN, glyceryl trinitrate.

Mentions: To investigate the effect of GTN on MIC A/B expression, total RNA and protein was extracted from the tumors. No significant difference in MIC A/B mRNA expression was identified between the GTN and placebo groups (Fig. 5 and Table V; P>0.05). However, at the protein level, MIC A/B expression was significantly higher in the GTN group compared with that of the placebo group (Fig. 6 and Table VI; P<0.01).


Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Relative expression of MIC A/B mRNA in tumors. MIC A/B, major histocompatibility class I-related chain A/B; GTN, glyceryl trinitrate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214498&req=5

f5-ol-08-06-2371: Relative expression of MIC A/B mRNA in tumors. MIC A/B, major histocompatibility class I-related chain A/B; GTN, glyceryl trinitrate.
Mentions: To investigate the effect of GTN on MIC A/B expression, total RNA and protein was extracted from the tumors. No significant difference in MIC A/B mRNA expression was identified between the GTN and placebo groups (Fig. 5 and Table V; P>0.05). However, at the protein level, MIC A/B expression was significantly higher in the GTN group compared with that of the placebo group (Fig. 6 and Table VI; P<0.01).

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus