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Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus

Tumor growth of the GTN and placebo groups. Tumor volume was monitored every 3–4 days. With increasing treatment time, the tumors of the GTN group were markedly smaller compared with those of the placebo group. GTN, glyceryl trinitrate.
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f2-ol-08-06-2371: Tumor growth of the GTN and placebo groups. Tumor volume was monitored every 3–4 days. With increasing treatment time, the tumors of the GTN group were markedly smaller compared with those of the placebo group. GTN, glyceryl trinitrate.

Mentions: The mice were sacrificed following 28 days of treatment. It was found that the tumors of the GTN group were markedly smaller than those of the placebo group (Figs. 1 and 2; Table I) and the inhibition ratio of tumor growth increased in a time-dependent manner (Fig. 3 and Table II).


Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.

Lu Y, Hu J, Sun W, Duan X, Chen X - Oncol Lett (2014)

Tumor growth of the GTN and placebo groups. Tumor volume was monitored every 3–4 days. With increasing treatment time, the tumors of the GTN group were markedly smaller compared with those of the placebo group. GTN, glyceryl trinitrate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214498&req=5

f2-ol-08-06-2371: Tumor growth of the GTN and placebo groups. Tumor volume was monitored every 3–4 days. With increasing treatment time, the tumors of the GTN group were markedly smaller compared with those of the placebo group. GTN, glyceryl trinitrate.
Mentions: The mice were sacrificed following 28 days of treatment. It was found that the tumors of the GTN group were markedly smaller than those of the placebo group (Figs. 1 and 2; Table I) and the inhibition ratio of tumor growth increased in a time-dependent manner (Fig. 3 and Table II).

Bottom Line: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice.The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group.The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

ABSTRACT
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

No MeSH data available.


Related in: MedlinePlus