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Granular cell tumor of the breast during lactation: A case report and review of the literature.

Qian X, Chen Y, Wan F - Oncol Lett (2014)

Bottom Line: In this tsudy, the case of a 29-year old female who presented with a mass in the right breast is decribed.Immunohistochemical and cytological analysis revealed a GCT and subsequently wide local excision was performed.Further studies are required to explore the association between granular cell tumors and hyperestrogenic and hyperprolactinemic states.

View Article: PubMed Central - PubMed

Affiliation: Ningbo Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang 315000, P.R. China.

ABSTRACT
Granular cell tumor of the breast (GCTB) is a rare tumor, particularly in lactating women. This tumor can clinically and radiologically mimic breast carcinoma, which poses particular problems. The association between GCTB and sex hormones should receive particular attention. The present study reports a case of GCTB in a lactating patient. In this tsudy, the case of a 29-year old female who presented with a mass in the right breast is decribed. Immunohistochemical and cytological analysis revealed a GCT and subsequently wide local excision was performed. At 15 months following surgery, the patient is well and no tumor recurrence has been identified. A comprehensive review of the literature was also performed to assess and compare all cases of GCTB, with particular attention to hyperestrogenic and hyperprolactinemic states. Further studies are required to explore the association between granular cell tumors and hyperestrogenic and hyperprolactinemic states.

No MeSH data available.


Related in: MedlinePlus

Cut surface of the resected specimen (black arrow) revealing a typical stellate-appearing fibrous area within fat tissue.
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f4-ol-08-06-2565: Cut surface of the resected specimen (black arrow) revealing a typical stellate-appearing fibrous area within fat tissue.

Mentions: An ultrasound-guided core biopsy was performed and confirmed that the mass was a GCT, due to the cytological features observed and the immunohistochemical profile of the mass, thus, a wide local excision was performed. The intraoperative frozen section demonstrated that the mass was a GCT. On gross examination, the surgically excised specimen was comprised of fatty tissue fragments measuring 2.5×2.0×2.0 cm, and contained a firm, well-limited and yellow-white nodule (Fig. 4). Microscopically, the specimen was composed of nests or sheets of cells that contained cytoplasmic eosinophilic granules. The cells were generally uniform, large and polygonal. The nuclei were round to oval in shape, and the nucleoli were prominent (Fig. 5A). Immunohistochemical staining was strongly positive for cluster of differentiation (CD)68 (Fig. 5B) and S100 expression (Fig. 5C) and negative for cytokeratin expression (Fig. 5D). The GCT diagnosis was confirmed. The patient received no further treatment, and 15 months after surgery was in good health, with no tumor recurrence.


Granular cell tumor of the breast during lactation: A case report and review of the literature.

Qian X, Chen Y, Wan F - Oncol Lett (2014)

Cut surface of the resected specimen (black arrow) revealing a typical stellate-appearing fibrous area within fat tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214494&req=5

f4-ol-08-06-2565: Cut surface of the resected specimen (black arrow) revealing a typical stellate-appearing fibrous area within fat tissue.
Mentions: An ultrasound-guided core biopsy was performed and confirmed that the mass was a GCT, due to the cytological features observed and the immunohistochemical profile of the mass, thus, a wide local excision was performed. The intraoperative frozen section demonstrated that the mass was a GCT. On gross examination, the surgically excised specimen was comprised of fatty tissue fragments measuring 2.5×2.0×2.0 cm, and contained a firm, well-limited and yellow-white nodule (Fig. 4). Microscopically, the specimen was composed of nests or sheets of cells that contained cytoplasmic eosinophilic granules. The cells were generally uniform, large and polygonal. The nuclei were round to oval in shape, and the nucleoli were prominent (Fig. 5A). Immunohistochemical staining was strongly positive for cluster of differentiation (CD)68 (Fig. 5B) and S100 expression (Fig. 5C) and negative for cytokeratin expression (Fig. 5D). The GCT diagnosis was confirmed. The patient received no further treatment, and 15 months after surgery was in good health, with no tumor recurrence.

Bottom Line: In this tsudy, the case of a 29-year old female who presented with a mass in the right breast is decribed.Immunohistochemical and cytological analysis revealed a GCT and subsequently wide local excision was performed.Further studies are required to explore the association between granular cell tumors and hyperestrogenic and hyperprolactinemic states.

View Article: PubMed Central - PubMed

Affiliation: Ningbo Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang 315000, P.R. China.

ABSTRACT
Granular cell tumor of the breast (GCTB) is a rare tumor, particularly in lactating women. This tumor can clinically and radiologically mimic breast carcinoma, which poses particular problems. The association between GCTB and sex hormones should receive particular attention. The present study reports a case of GCTB in a lactating patient. In this tsudy, the case of a 29-year old female who presented with a mass in the right breast is decribed. Immunohistochemical and cytological analysis revealed a GCT and subsequently wide local excision was performed. At 15 months following surgery, the patient is well and no tumor recurrence has been identified. A comprehensive review of the literature was also performed to assess and compare all cases of GCTB, with particular attention to hyperestrogenic and hyperprolactinemic states. Further studies are required to explore the association between granular cell tumors and hyperestrogenic and hyperprolactinemic states.

No MeSH data available.


Related in: MedlinePlus