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Tumor-targeting bacterial therapy: A potential treatment for oral cancer (Review).

Liu S, Xu X, Zeng X, Li L, Chen Q, Li J - Oncol Lett (2014)

Bottom Line: As genetically manipulated bacteria may actively and specifically penetrate into the tumor tissue, bacterial therapy is becoming a promising approach in the treatment of tumors.However, to the best of our knowledge, no reports have been published thus far regarding the bacterial treatment of oral cancer, one of the most common types of cancer worldwide.In this review, the progress in the understanding of bacterial strategies used in tumor-targeted therapy is discussed and particular bacterial strains that may have great therapeutic potential in oral squamous cell carcinoma (OSCC) tumor-targeted therapy are predicted as determined by previous studies.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

ABSTRACT
Certain obligate or facultative anaerobic bacteria, which exhibit an inherent ability to colonize solid tumors in vivo, may be used in tumor targeting. As genetically manipulated bacteria may actively and specifically penetrate into the tumor tissue, bacterial therapy is becoming a promising approach in the treatment of tumors. However, to the best of our knowledge, no reports have been published thus far regarding the bacterial treatment of oral cancer, one of the most common types of cancer worldwide. In this review, the progress in the understanding of bacterial strategies used in tumor-targeted therapy is discussed and particular bacterial strains that may have great therapeutic potential in oral squamous cell carcinoma (OSCC) tumor-targeted therapy are predicted as determined by previous studies.

No MeSH data available.


Related in: MedlinePlus

Strategies in tumor-targeting bacterial therapy. (A) Bacteria have adequate tissue penetrating ability. Anaerobic bacteria, which only colonize in areas devoid of oxygen, may actively swim away from the vasculature, penetrate deep into tumor tissue and accumulate following systematic injection (pink syringe), a property traditional chemotherapy (green syringe) does not possess. (B) Delivery of anticancer agents. Bacteria have the ability to manufacture and deliver specific materials, which may be coupled with particular anticancer agents. Engineered bacteria kill cancer cells by expressing proteins that act against tumors (e.g. cytotoxic agents, cytokines, antibodies, cytotoxins, antiangiogenic agents and enzymes that convert the nonfunctional prodrug to an active anticancer drug) and transferring eukaryotic expression vectors into infected cancer cells. (C) Bacteria in oncolytic therapy. Anaerobic bacteria swim into tumor tissue, multiply in the hypoxic/necrotic areas and directly kill tumor cells.
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f1-ol-08-06-2359: Strategies in tumor-targeting bacterial therapy. (A) Bacteria have adequate tissue penetrating ability. Anaerobic bacteria, which only colonize in areas devoid of oxygen, may actively swim away from the vasculature, penetrate deep into tumor tissue and accumulate following systematic injection (pink syringe), a property traditional chemotherapy (green syringe) does not possess. (B) Delivery of anticancer agents. Bacteria have the ability to manufacture and deliver specific materials, which may be coupled with particular anticancer agents. Engineered bacteria kill cancer cells by expressing proteins that act against tumors (e.g. cytotoxic agents, cytokines, antibodies, cytotoxins, antiangiogenic agents and enzymes that convert the nonfunctional prodrug to an active anticancer drug) and transferring eukaryotic expression vectors into infected cancer cells. (C) Bacteria in oncolytic therapy. Anaerobic bacteria swim into tumor tissue, multiply in the hypoxic/necrotic areas and directly kill tumor cells.

Mentions: The hypothesis that living bacteria may function as anticancer therapeutic agents was first advanced in the middle of the twentieth century. Due to the obstacles of hypoxia and necrosis, accessing tumor tissue with traditional treatments has proved difficult. However, bacteria may actively migrate away from the vasculature and penetrate deep into tumor tissue and accumulate (Fig. 1A). Three classes of anaerobic and facultative anaerobes have been examined for use in anticancer therapy (16,17): Bifidobacteria, facultative intracellular bacteria and strictly anaerobic bacteria.


Tumor-targeting bacterial therapy: A potential treatment for oral cancer (Review).

Liu S, Xu X, Zeng X, Li L, Chen Q, Li J - Oncol Lett (2014)

Strategies in tumor-targeting bacterial therapy. (A) Bacteria have adequate tissue penetrating ability. Anaerobic bacteria, which only colonize in areas devoid of oxygen, may actively swim away from the vasculature, penetrate deep into tumor tissue and accumulate following systematic injection (pink syringe), a property traditional chemotherapy (green syringe) does not possess. (B) Delivery of anticancer agents. Bacteria have the ability to manufacture and deliver specific materials, which may be coupled with particular anticancer agents. Engineered bacteria kill cancer cells by expressing proteins that act against tumors (e.g. cytotoxic agents, cytokines, antibodies, cytotoxins, antiangiogenic agents and enzymes that convert the nonfunctional prodrug to an active anticancer drug) and transferring eukaryotic expression vectors into infected cancer cells. (C) Bacteria in oncolytic therapy. Anaerobic bacteria swim into tumor tissue, multiply in the hypoxic/necrotic areas and directly kill tumor cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214492&req=5

f1-ol-08-06-2359: Strategies in tumor-targeting bacterial therapy. (A) Bacteria have adequate tissue penetrating ability. Anaerobic bacteria, which only colonize in areas devoid of oxygen, may actively swim away from the vasculature, penetrate deep into tumor tissue and accumulate following systematic injection (pink syringe), a property traditional chemotherapy (green syringe) does not possess. (B) Delivery of anticancer agents. Bacteria have the ability to manufacture and deliver specific materials, which may be coupled with particular anticancer agents. Engineered bacteria kill cancer cells by expressing proteins that act against tumors (e.g. cytotoxic agents, cytokines, antibodies, cytotoxins, antiangiogenic agents and enzymes that convert the nonfunctional prodrug to an active anticancer drug) and transferring eukaryotic expression vectors into infected cancer cells. (C) Bacteria in oncolytic therapy. Anaerobic bacteria swim into tumor tissue, multiply in the hypoxic/necrotic areas and directly kill tumor cells.
Mentions: The hypothesis that living bacteria may function as anticancer therapeutic agents was first advanced in the middle of the twentieth century. Due to the obstacles of hypoxia and necrosis, accessing tumor tissue with traditional treatments has proved difficult. However, bacteria may actively migrate away from the vasculature and penetrate deep into tumor tissue and accumulate (Fig. 1A). Three classes of anaerobic and facultative anaerobes have been examined for use in anticancer therapy (16,17): Bifidobacteria, facultative intracellular bacteria and strictly anaerobic bacteria.

Bottom Line: As genetically manipulated bacteria may actively and specifically penetrate into the tumor tissue, bacterial therapy is becoming a promising approach in the treatment of tumors.However, to the best of our knowledge, no reports have been published thus far regarding the bacterial treatment of oral cancer, one of the most common types of cancer worldwide.In this review, the progress in the understanding of bacterial strategies used in tumor-targeted therapy is discussed and particular bacterial strains that may have great therapeutic potential in oral squamous cell carcinoma (OSCC) tumor-targeted therapy are predicted as determined by previous studies.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

ABSTRACT
Certain obligate or facultative anaerobic bacteria, which exhibit an inherent ability to colonize solid tumors in vivo, may be used in tumor targeting. As genetically manipulated bacteria may actively and specifically penetrate into the tumor tissue, bacterial therapy is becoming a promising approach in the treatment of tumors. However, to the best of our knowledge, no reports have been published thus far regarding the bacterial treatment of oral cancer, one of the most common types of cancer worldwide. In this review, the progress in the understanding of bacterial strategies used in tumor-targeted therapy is discussed and particular bacterial strains that may have great therapeutic potential in oral squamous cell carcinoma (OSCC) tumor-targeted therapy are predicted as determined by previous studies.

No MeSH data available.


Related in: MedlinePlus