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Renal hemangiopericytoma secondary to refractory hypertension in a child: A case report.

Hu Q, Fang Z, Zhou Z, Zheng J - Oncol Lett (2014)

Bottom Line: The majority of cases are identified in patients between the ages of 20 and 50 years of age, and a considerable proportion of patients exhibit hypertension, hypoglycaemia or additional paraneoplastic syndromes.Following the complete resection of the tumor, the patient's blood pressure returned to normal.Furthermore, this case also demonstrated that secondary hypertension may also recover following tumor excision.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

ABSTRACT
Hemangiopericytoma is a rare perivascular tumor that often involves the extremities, pelvis, head and neck, and meninges, but rarely occurs in the kidney. The differentiation from renal cancer prior to surgery is extremely challenging; therefore, almost all cases of renal hemangiopericytoma are diagnosed by pathological examination. The majority of cases are identified in patients between the ages of 20 and 50 years of age, and a considerable proportion of patients exhibit hypertension, hypoglycaemia or additional paraneoplastic syndromes. The current study reports a rare case of renal hemangiopericytoma with drug refractory hypertension in a 14-year-old female. Following the complete resection of the tumor, the patient's blood pressure returned to normal. No evidence of recurrence or metastasis was observed during a follow-up of 12 months following surgery. The present case indicated that surgery provides satisfactory outcomes and appears to be the most effective modality of treatment for renal hemangiopericytoma. Furthermore, this case also demonstrated that secondary hypertension may also recover following tumor excision.

No MeSH data available.


Related in: MedlinePlus

Microscopic examination in absence of immunohistochemical staining (stain, hematoxylin and eosin; magnification,10×20).
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f2-ol-08-06-2493: Microscopic examination in absence of immunohistochemical staining (stain, hematoxylin and eosin; magnification,10×20).

Mentions: Partial nephrectomy with an open, lumbotomic approach was implemented for this renal lesion with unknown characteristics. An exophytic and clear, circumscribed tumor was excised completely. The specimen was 3.5 cm in diameter, and a homogeneous texture without necrosis or cystic separation was visible on gross examination. On microscopic examination, monotonous proliferation with no significant variability and pericytes around the endothelial vascular channels were the characteristic features, which indicated renal hemangiopericytoma (Fig, 2). The positive results of vimentin, Bcl-2 and CD34 by immunohistochemical staining also supported this diagnosis (Fig. 3).


Renal hemangiopericytoma secondary to refractory hypertension in a child: A case report.

Hu Q, Fang Z, Zhou Z, Zheng J - Oncol Lett (2014)

Microscopic examination in absence of immunohistochemical staining (stain, hematoxylin and eosin; magnification,10×20).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214483&req=5

f2-ol-08-06-2493: Microscopic examination in absence of immunohistochemical staining (stain, hematoxylin and eosin; magnification,10×20).
Mentions: Partial nephrectomy with an open, lumbotomic approach was implemented for this renal lesion with unknown characteristics. An exophytic and clear, circumscribed tumor was excised completely. The specimen was 3.5 cm in diameter, and a homogeneous texture without necrosis or cystic separation was visible on gross examination. On microscopic examination, monotonous proliferation with no significant variability and pericytes around the endothelial vascular channels were the characteristic features, which indicated renal hemangiopericytoma (Fig, 2). The positive results of vimentin, Bcl-2 and CD34 by immunohistochemical staining also supported this diagnosis (Fig. 3).

Bottom Line: The majority of cases are identified in patients between the ages of 20 and 50 years of age, and a considerable proportion of patients exhibit hypertension, hypoglycaemia or additional paraneoplastic syndromes.Following the complete resection of the tumor, the patient's blood pressure returned to normal.Furthermore, this case also demonstrated that secondary hypertension may also recover following tumor excision.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

ABSTRACT
Hemangiopericytoma is a rare perivascular tumor that often involves the extremities, pelvis, head and neck, and meninges, but rarely occurs in the kidney. The differentiation from renal cancer prior to surgery is extremely challenging; therefore, almost all cases of renal hemangiopericytoma are diagnosed by pathological examination. The majority of cases are identified in patients between the ages of 20 and 50 years of age, and a considerable proportion of patients exhibit hypertension, hypoglycaemia or additional paraneoplastic syndromes. The current study reports a rare case of renal hemangiopericytoma with drug refractory hypertension in a 14-year-old female. Following the complete resection of the tumor, the patient's blood pressure returned to normal. No evidence of recurrence or metastasis was observed during a follow-up of 12 months following surgery. The present case indicated that surgery provides satisfactory outcomes and appears to be the most effective modality of treatment for renal hemangiopericytoma. Furthermore, this case also demonstrated that secondary hypertension may also recover following tumor excision.

No MeSH data available.


Related in: MedlinePlus