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Intraductal carcinoma and carcinosarcoma with bone metastases presenting in one breast: A case report.

Zhong X, Shen H, Yuan Y - Oncol Lett (2014)

Bottom Line: Mammography and magnetic resonance imaging revealed two small masses, which were <1 cm in diameter.Positron emission tomography/computed tomography showed a maximum standardized uptake volume of 3.46 for one soft tissue nodule and multiple bones that were exhibiting radioactive enhancement.The response to chemotherapy was poor and the patient succumbed to the disease within one month of diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China ; Department of Medical Oncology, Hangzhou Binjiang Hospital, Hangzhou, Zhejiang 310052, P.R. China.

ABSTRACT
Carcinosarcoma of the breast is an extremely rare and clinically aggressive tumor possessing carcinomatous components and malignant mesenchymal elements, with few cases reported in the literature. The prognosis of breast carcinosarcoma is poor when compared with more common types of breast cancer, such as ductal or lobular carcinoma. Furthermore, carcinosarcoma presents a diagnostic and therapeutic challenge due to the diversity in histology pattern and the lack of consensus regarding diagnostic criteria and effective systemic management. A 51-year-old female presented to the Department of Medical Oncology of the Second Affiliated Hospital of Zhejiang University (Hangzhou, China) with the complaint of lumbago and physical examination revealed a small mass in the right breast near the areola. Mammography and magnetic resonance imaging revealed two small masses, which were <1 cm in diameter. Positron emission tomography/computed tomography showed a maximum standardized uptake volume of 3.46 for one soft tissue nodule and multiple bones that were exhibiting radioactive enhancement. The patient was diagnosed with a breast carcinosarcoma with bone metastases and breast intraductal carcinoma. The response to chemotherapy was poor and the patient succumbed to the disease within one month of diagnosis.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging revealed two nodules proximal to the areola of the right breast.
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f2-ol-08-06-2678: Magnetic resonance imaging revealed two nodules proximal to the areola of the right breast.

Mentions: A 51-year-old Mongolian female presented to the Department of Medical Oncology of the Second Affiliated Hospital of Zhejiang University (Hangzhou, China) with the complaint of lumbago that had persisted for two months. The patient’s first-degree relatives had no history of cancer. On physical examination, a 0.5×0.5-cm mass was identified in the right breast near the areola. Bilateral axillary examination revealed no lymphadenopathy. Sonography detected two masses near the areola of the right breast; one mass measured 0.6×0.5 cm and the second mass measured 0.9×0.6 cm and was proximal to the ectopectoralis. Ultrasound examination of the bilateral axillary fossa was unremarkable. However, the patient’s mammogram was abnormal and revealed two masses in the right breast, which were situated in the upper inner and upper outer quadrants (Fig. 1). Magnetic resonance imaging (MRI) of the breast also revealed two nodules near the areola of the right breast (Fig. 2). The first node was 7 mm in diameter and located within the catheter, 30 mm from the nipple and was enhanced significantly following injection of a contrast agent. The second node was 8 mm in diameter and was proximal o the basilar section of the right breast. Positron emission tomography/computed tomography revealed an 8.1-mm soft tissue nodule with a sublobe in the upper inner quadrant of the right breast (maximum standardized uptake volume, 3.46). Radioactive enhancement was observed in multiple bones (each side of the scapula and femur, the sternum, the left eighth rib, and between the ninth thoracic and second sacral vertebrae). Based on these results, the primary diagnosis was determined as breast cancer with bone metastases.


Intraductal carcinoma and carcinosarcoma with bone metastases presenting in one breast: A case report.

Zhong X, Shen H, Yuan Y - Oncol Lett (2014)

Magnetic resonance imaging revealed two nodules proximal to the areola of the right breast.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214474&req=5

f2-ol-08-06-2678: Magnetic resonance imaging revealed two nodules proximal to the areola of the right breast.
Mentions: A 51-year-old Mongolian female presented to the Department of Medical Oncology of the Second Affiliated Hospital of Zhejiang University (Hangzhou, China) with the complaint of lumbago that had persisted for two months. The patient’s first-degree relatives had no history of cancer. On physical examination, a 0.5×0.5-cm mass was identified in the right breast near the areola. Bilateral axillary examination revealed no lymphadenopathy. Sonography detected two masses near the areola of the right breast; one mass measured 0.6×0.5 cm and the second mass measured 0.9×0.6 cm and was proximal to the ectopectoralis. Ultrasound examination of the bilateral axillary fossa was unremarkable. However, the patient’s mammogram was abnormal and revealed two masses in the right breast, which were situated in the upper inner and upper outer quadrants (Fig. 1). Magnetic resonance imaging (MRI) of the breast also revealed two nodules near the areola of the right breast (Fig. 2). The first node was 7 mm in diameter and located within the catheter, 30 mm from the nipple and was enhanced significantly following injection of a contrast agent. The second node was 8 mm in diameter and was proximal o the basilar section of the right breast. Positron emission tomography/computed tomography revealed an 8.1-mm soft tissue nodule with a sublobe in the upper inner quadrant of the right breast (maximum standardized uptake volume, 3.46). Radioactive enhancement was observed in multiple bones (each side of the scapula and femur, the sternum, the left eighth rib, and between the ninth thoracic and second sacral vertebrae). Based on these results, the primary diagnosis was determined as breast cancer with bone metastases.

Bottom Line: Mammography and magnetic resonance imaging revealed two small masses, which were <1 cm in diameter.Positron emission tomography/computed tomography showed a maximum standardized uptake volume of 3.46 for one soft tissue nodule and multiple bones that were exhibiting radioactive enhancement.The response to chemotherapy was poor and the patient succumbed to the disease within one month of diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China ; Department of Medical Oncology, Hangzhou Binjiang Hospital, Hangzhou, Zhejiang 310052, P.R. China.

ABSTRACT
Carcinosarcoma of the breast is an extremely rare and clinically aggressive tumor possessing carcinomatous components and malignant mesenchymal elements, with few cases reported in the literature. The prognosis of breast carcinosarcoma is poor when compared with more common types of breast cancer, such as ductal or lobular carcinoma. Furthermore, carcinosarcoma presents a diagnostic and therapeutic challenge due to the diversity in histology pattern and the lack of consensus regarding diagnostic criteria and effective systemic management. A 51-year-old female presented to the Department of Medical Oncology of the Second Affiliated Hospital of Zhejiang University (Hangzhou, China) with the complaint of lumbago and physical examination revealed a small mass in the right breast near the areola. Mammography and magnetic resonance imaging revealed two small masses, which were <1 cm in diameter. Positron emission tomography/computed tomography showed a maximum standardized uptake volume of 3.46 for one soft tissue nodule and multiple bones that were exhibiting radioactive enhancement. The patient was diagnosed with a breast carcinosarcoma with bone metastases and breast intraductal carcinoma. The response to chemotherapy was poor and the patient succumbed to the disease within one month of diagnosis.

No MeSH data available.


Related in: MedlinePlus