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Mesenchymal chondrosarcoma of the right buccal region: A case report and review of the literature.

Yu L, Li M, Lin R, Mu Y, Zhao J - Oncol Lett (2014)

Bottom Line: In this study, the case of primary EMCS arising from the right buccal region in a 26-year old female is presented.To the best of our knowledge, only one case of primary EMCS of the buccal region has been reported previously.In the current study, a case of primary EMCS of the buccal region is presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.

ABSTRACT
Extraskeletal mesenchymal chondrosarcoma (EMCS) is a rare malignant cartilaginous tumor arising from the soft tissues. The most common areas of extraskeletal origin are the lower extremities, the orbits and the central nervous system, among others. In this study, the case of primary EMCS arising from the right buccal region in a 26-year old female is presented. Histological and immunohistochemical analysis confirmed the diagnosis of EMCS. Subseqently, the patient was treated with radical surgery, but declined chemotherapy or radiotherapy, which was recommended. One year after surgery, no recurrence had been identified in the patient. To the best of our knowledge, only one case of primary EMCS of the buccal region has been reported previously. In the current study, a case of primary EMCS of the buccal region is presented.

No MeSH data available.


Related in: MedlinePlus

Pathological specimens revealing (A) a hemangioperictyoma-like vascular pattern, with proliferation of small, round and undifferentiated mesenchymal cells with clear cytoplasm and (B) small round cells surrounding the blood vessels and enveloping the differentiated cartilage (stain, hematoxylin and eosin; magnification, ×200).
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f3-ol-08-06-2557: Pathological specimens revealing (A) a hemangioperictyoma-like vascular pattern, with proliferation of small, round and undifferentiated mesenchymal cells with clear cytoplasm and (B) small round cells surrounding the blood vessels and enveloping the differentiated cartilage (stain, hematoxylin and eosin; magnification, ×200).

Mentions: A 26-year-old female, with no medical history, presented to the surgical Out-patients Department of the Oral and Maxillofacial Surgery of Peking University Medical College Hospital (Chinese Academy of Medical Sciences, Beijing, China), with the chief complaint of a mass in the right buccal region. The mass was painless and had gradually increased in size for 12 months. Six months previously, upon investigation at another hospital, apparent upper mandibular lymph node swelling was detected in the right buccal region. The patient was provisionally diagnosed with lymph node inflammation and was treated with antibiotics. However, the patient’s condition deteriorated two weeks prior to the presentation to the Peking University Medical College Hospital. Extraoral examination revealed a firm mass measuring ~3×2.5 cm in size, without fixation to the mandible. The overlying skin color and texture was normal. The mass was well defined and lobulated on palpation. The facial nerve was not involved with the tumor. A physical examination and chest X-ray revealed no clinical evidence of distant metastasis. Computed tomography (CT) scans revealed a well-defined mass, without involvement of the mandible (Figs. 1 and 2). The mass was widely resected under general anesthesia and was subsequently histopathologically investigated. The post-operative course was uneventful. The gross appearance of the mass was typically grey or tan in color and poorly circumscribed. Microscopy revealed a tumor composed of islands of well-differentiated cartilage surrounded by areas of ovoid- and spindle-shaped cells exhibiting a hemangiopericytomatous pattern (Figs. 3 and 4). Focal calcification was observed in chondroid areas. Immunohistochemical analysis of the tumor cells revealed positivity for vimentin, S-100, AE1/AE3, B-cell lymphoma-2, cluster of differentiation (CD)99 and leukocyte common antigen, and negativity for desmin, epithelial membrane antigen (EMA) and CD34. Histology and immunohistochemistry indicated the diagnosis of EMCS. The patient declined chemotherapy and radiotherapy, but continued to attend follow-up appointments. No local recurrence or metastasis was identified following surgery. To date, no local reccurence or metastasis has been identified in the patient.


Mesenchymal chondrosarcoma of the right buccal region: A case report and review of the literature.

Yu L, Li M, Lin R, Mu Y, Zhao J - Oncol Lett (2014)

Pathological specimens revealing (A) a hemangioperictyoma-like vascular pattern, with proliferation of small, round and undifferentiated mesenchymal cells with clear cytoplasm and (B) small round cells surrounding the blood vessels and enveloping the differentiated cartilage (stain, hematoxylin and eosin; magnification, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214473&req=5

f3-ol-08-06-2557: Pathological specimens revealing (A) a hemangioperictyoma-like vascular pattern, with proliferation of small, round and undifferentiated mesenchymal cells with clear cytoplasm and (B) small round cells surrounding the blood vessels and enveloping the differentiated cartilage (stain, hematoxylin and eosin; magnification, ×200).
Mentions: A 26-year-old female, with no medical history, presented to the surgical Out-patients Department of the Oral and Maxillofacial Surgery of Peking University Medical College Hospital (Chinese Academy of Medical Sciences, Beijing, China), with the chief complaint of a mass in the right buccal region. The mass was painless and had gradually increased in size for 12 months. Six months previously, upon investigation at another hospital, apparent upper mandibular lymph node swelling was detected in the right buccal region. The patient was provisionally diagnosed with lymph node inflammation and was treated with antibiotics. However, the patient’s condition deteriorated two weeks prior to the presentation to the Peking University Medical College Hospital. Extraoral examination revealed a firm mass measuring ~3×2.5 cm in size, without fixation to the mandible. The overlying skin color and texture was normal. The mass was well defined and lobulated on palpation. The facial nerve was not involved with the tumor. A physical examination and chest X-ray revealed no clinical evidence of distant metastasis. Computed tomography (CT) scans revealed a well-defined mass, without involvement of the mandible (Figs. 1 and 2). The mass was widely resected under general anesthesia and was subsequently histopathologically investigated. The post-operative course was uneventful. The gross appearance of the mass was typically grey or tan in color and poorly circumscribed. Microscopy revealed a tumor composed of islands of well-differentiated cartilage surrounded by areas of ovoid- and spindle-shaped cells exhibiting a hemangiopericytomatous pattern (Figs. 3 and 4). Focal calcification was observed in chondroid areas. Immunohistochemical analysis of the tumor cells revealed positivity for vimentin, S-100, AE1/AE3, B-cell lymphoma-2, cluster of differentiation (CD)99 and leukocyte common antigen, and negativity for desmin, epithelial membrane antigen (EMA) and CD34. Histology and immunohistochemistry indicated the diagnosis of EMCS. The patient declined chemotherapy and radiotherapy, but continued to attend follow-up appointments. No local recurrence or metastasis was identified following surgery. To date, no local reccurence or metastasis has been identified in the patient.

Bottom Line: In this study, the case of primary EMCS arising from the right buccal region in a 26-year old female is presented.To the best of our knowledge, only one case of primary EMCS of the buccal region has been reported previously.In the current study, a case of primary EMCS of the buccal region is presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.

ABSTRACT
Extraskeletal mesenchymal chondrosarcoma (EMCS) is a rare malignant cartilaginous tumor arising from the soft tissues. The most common areas of extraskeletal origin are the lower extremities, the orbits and the central nervous system, among others. In this study, the case of primary EMCS arising from the right buccal region in a 26-year old female is presented. Histological and immunohistochemical analysis confirmed the diagnosis of EMCS. Subseqently, the patient was treated with radical surgery, but declined chemotherapy or radiotherapy, which was recommended. One year after surgery, no recurrence had been identified in the patient. To the best of our knowledge, only one case of primary EMCS of the buccal region has been reported previously. In the current study, a case of primary EMCS of the buccal region is presented.

No MeSH data available.


Related in: MedlinePlus