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Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature.

Wang JH, Chen L, Ren K - Oncol Lett (2014)

Bottom Line: On color Doppler ultrasound, the PTL was shown as a significantly enlarged thyroid with reduced gland echoes.PTL exhibits specific features on medical imaging that aid in distinguishing it from other thyroid diseases.PTL exhibits specific features on medical imaging that aid in distinguishing PTL from other thyroid diseases, which may aid the support for clinical diagnosis and improve the clinical accuracy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China ; Department of Radiology, Jilin Central Hospital, Jilin City, Jilin 132000, P.R. China.

ABSTRACT
Primary thyroid lymphoma (PTL) is a rare thyroid malignancy. Clinical diagnosis of PTL may not be easily established based on imaging studies, as the imaging features of PTL are similar to those of lymphocytic thyroiditis and primary thyroid cancer. The present study describes the case of a patient who was confirmed to have PTL by intra-operative pathological diagnosis. On color Doppler ultrasound, the PTL was shown as a significantly enlarged thyroid with reduced gland echoes. Color Doppler flow imaging showed increased blood flow. By computed tomography, the thyroid was revealed to be enlarged with reduced tissue density, particularly in the left lobe and the isthmus. In addition, calcified spots and swollen lymph nodes were evident. The clinical history of the patient was obtained and the imaging results were retrospectively analyzed. The imaging features of PTL were investigated through reviewing the literature. PTL exhibits specific features on medical imaging that aid in distinguishing it from other thyroid diseases. PTL exhibits specific features on medical imaging that aid in distinguishing PTL from other thyroid diseases, which may aid the support for clinical diagnosis and improve the clinical accuracy.

No MeSH data available.


Related in: MedlinePlus

Pathological confirmation of non-Hodgkin’s lymphoma by diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli, and the appearance of mitosis (staining, hematoxylin and eosin; magnification, ×20).
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f3-ol-08-06-2505: Pathological confirmation of non-Hodgkin’s lymphoma by diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli, and the appearance of mitosis (staining, hematoxylin and eosin; magnification, ×20).

Mentions: Surgery was performed one month after the patient’s initial visit, as the patient experienced worsened dysphagia. During surgery, a 9.0×12.0-cm firm tumor was observed to adhere to the cervical muscle, with a fish-flesh appearance and no complete capsule. Rapid intraoperative pathological diagnosis showed thyroid malignancy, thus lymphoma was indicated. Partial resection was performed due to difficulties in complete surgical resection. Immunohistochemical analysis showed that antigens associated with B cells, such as cluster of differentiation 20 (CD20), CD22 and CD79a (7–9), were widely expressed, suggesting B-cell lymphoma. Postoperative pathological examination (Fig. 3) confirmed diffuse large B-cell lymphoma by the diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli and the appearance of mitosis.


Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature.

Wang JH, Chen L, Ren K - Oncol Lett (2014)

Pathological confirmation of non-Hodgkin’s lymphoma by diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli, and the appearance of mitosis (staining, hematoxylin and eosin; magnification, ×20).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214466&req=5

f3-ol-08-06-2505: Pathological confirmation of non-Hodgkin’s lymphoma by diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli, and the appearance of mitosis (staining, hematoxylin and eosin; magnification, ×20).
Mentions: Surgery was performed one month after the patient’s initial visit, as the patient experienced worsened dysphagia. During surgery, a 9.0×12.0-cm firm tumor was observed to adhere to the cervical muscle, with a fish-flesh appearance and no complete capsule. Rapid intraoperative pathological diagnosis showed thyroid malignancy, thus lymphoma was indicated. Partial resection was performed due to difficulties in complete surgical resection. Immunohistochemical analysis showed that antigens associated with B cells, such as cluster of differentiation 20 (CD20), CD22 and CD79a (7–9), were widely expressed, suggesting B-cell lymphoma. Postoperative pathological examination (Fig. 3) confirmed diffuse large B-cell lymphoma by the diffuse proliferation of large atypical lymphocytes, large nuclei with coarse nuclear reticulum, including several small nucleoli and the appearance of mitosis.

Bottom Line: On color Doppler ultrasound, the PTL was shown as a significantly enlarged thyroid with reduced gland echoes.PTL exhibits specific features on medical imaging that aid in distinguishing it from other thyroid diseases.PTL exhibits specific features on medical imaging that aid in distinguishing PTL from other thyroid diseases, which may aid the support for clinical diagnosis and improve the clinical accuracy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China ; Department of Radiology, Jilin Central Hospital, Jilin City, Jilin 132000, P.R. China.

ABSTRACT
Primary thyroid lymphoma (PTL) is a rare thyroid malignancy. Clinical diagnosis of PTL may not be easily established based on imaging studies, as the imaging features of PTL are similar to those of lymphocytic thyroiditis and primary thyroid cancer. The present study describes the case of a patient who was confirmed to have PTL by intra-operative pathological diagnosis. On color Doppler ultrasound, the PTL was shown as a significantly enlarged thyroid with reduced gland echoes. Color Doppler flow imaging showed increased blood flow. By computed tomography, the thyroid was revealed to be enlarged with reduced tissue density, particularly in the left lobe and the isthmus. In addition, calcified spots and swollen lymph nodes were evident. The clinical history of the patient was obtained and the imaging results were retrospectively analyzed. The imaging features of PTL were investigated through reviewing the literature. PTL exhibits specific features on medical imaging that aid in distinguishing it from other thyroid diseases. PTL exhibits specific features on medical imaging that aid in distinguishing PTL from other thyroid diseases, which may aid the support for clinical diagnosis and improve the clinical accuracy.

No MeSH data available.


Related in: MedlinePlus