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Keratin 5 expression in squamocellular carcinoma of the head and neck.

Vasca V, Vasca E, Freiman P, Marian D, Luce A, Mesolella M, Caraglia M, Ricciardiello F, Duminica T - Oncol Lett (2014)

Bottom Line: A total of 13 biopsy fragments were included from patients diagnosed with squamocellular carcinoma of the larynx area (n=2), pharynx (n=2), hard palate (n=1), tongue (n=2), submandibular (n=1), lip (n=1), gingival sulcus (n=1), nasal pyramid (n=1), maxilla (n=1) and zygomatic (n=1).For well- and moderately-differentiated histopathological types, a maximum score of 3 was recorded for all of the cases, not including the laryngeal area, which presented a score of 2.These observations may aid with an improved stratification of head and neck squamocellular carcinoma, thus improving the diagnosis and treatment strategies for this type of cancer.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, Pharmacy and Dental Medicine, 'Vasile Goldiş' Western University of Arad, Arad 310025, Romania.

ABSTRACT
Keratin 5 (K5) is present in the basal layer of a stratified squamous keratinized and non-keratinized epithelium. K5 and K14 have been demonstrated in the mucosa and tumors of the oral cavity, oropharynx, hypopharynx and larynx, and in the mitotic active basal cells of a stratified squamous epithelium. The aim of the present study was to assess K5 expression in squamocellular carcinoma with various localizations in the head and neck. A total of 13 biopsy fragments were included from patients diagnosed with squamocellular carcinoma of the larynx area (n=2), pharynx (n=2), hard palate (n=1), tongue (n=2), submandibular (n=1), lip (n=1), gingival sulcus (n=1), nasal pyramid (n=1), maxilla (n=1) and zygomatic (n=1). The immunohistochemical staining for K5 was evaluated according to the following score criteria: 0 (0% positive cells); 1 (<10% positive cells); 2 (10-30% positive cells); and 3 (>30% positive cells). K5 expression was observed in all squamocellular carcinomas included in the present study with scores between 1 and 3. For well- and moderately-differentiated histopathological types, a maximum score of 3 was recorded for all of the cases, not including the laryngeal area, which presented a score of 2. The following scores were identified in the regions of the poorly differentiated carcinomas: Jaw, 3; gingival sulcus, 2; and tongue and submandibular area, 1. These observations may aid with an improved stratification of head and neck squamocellular carcinoma, thus improving the diagnosis and treatment strategies for this type of cancer.

No MeSH data available.


Related in: MedlinePlus

Ratio between the values of the score that indicates the percentage of the positive cytokeratin 5 tumoral cells and the various areas where the squamocellular carcinomas were located.
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f5-ol-08-06-2501: Ratio between the values of the score that indicates the percentage of the positive cytokeratin 5 tumoral cells and the various areas where the squamocellular carcinomas were located.

Mentions: The squamocellular carcinoma that originated from the gingival sulcus area preserved the same mixed aspect with positive and negative cells present at the level of the tumor areas. In this case, the intensity of the reaction was moderate (score, 2) and the expression patterns were cytoplasmic or mixed (Figs. 4C and 5).


Keratin 5 expression in squamocellular carcinoma of the head and neck.

Vasca V, Vasca E, Freiman P, Marian D, Luce A, Mesolella M, Caraglia M, Ricciardiello F, Duminica T - Oncol Lett (2014)

Ratio between the values of the score that indicates the percentage of the positive cytokeratin 5 tumoral cells and the various areas where the squamocellular carcinomas were located.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214456&req=5

f5-ol-08-06-2501: Ratio between the values of the score that indicates the percentage of the positive cytokeratin 5 tumoral cells and the various areas where the squamocellular carcinomas were located.
Mentions: The squamocellular carcinoma that originated from the gingival sulcus area preserved the same mixed aspect with positive and negative cells present at the level of the tumor areas. In this case, the intensity of the reaction was moderate (score, 2) and the expression patterns were cytoplasmic or mixed (Figs. 4C and 5).

Bottom Line: A total of 13 biopsy fragments were included from patients diagnosed with squamocellular carcinoma of the larynx area (n=2), pharynx (n=2), hard palate (n=1), tongue (n=2), submandibular (n=1), lip (n=1), gingival sulcus (n=1), nasal pyramid (n=1), maxilla (n=1) and zygomatic (n=1).For well- and moderately-differentiated histopathological types, a maximum score of 3 was recorded for all of the cases, not including the laryngeal area, which presented a score of 2.These observations may aid with an improved stratification of head and neck squamocellular carcinoma, thus improving the diagnosis and treatment strategies for this type of cancer.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, Pharmacy and Dental Medicine, 'Vasile Goldiş' Western University of Arad, Arad 310025, Romania.

ABSTRACT
Keratin 5 (K5) is present in the basal layer of a stratified squamous keratinized and non-keratinized epithelium. K5 and K14 have been demonstrated in the mucosa and tumors of the oral cavity, oropharynx, hypopharynx and larynx, and in the mitotic active basal cells of a stratified squamous epithelium. The aim of the present study was to assess K5 expression in squamocellular carcinoma with various localizations in the head and neck. A total of 13 biopsy fragments were included from patients diagnosed with squamocellular carcinoma of the larynx area (n=2), pharynx (n=2), hard palate (n=1), tongue (n=2), submandibular (n=1), lip (n=1), gingival sulcus (n=1), nasal pyramid (n=1), maxilla (n=1) and zygomatic (n=1). The immunohistochemical staining for K5 was evaluated according to the following score criteria: 0 (0% positive cells); 1 (<10% positive cells); 2 (10-30% positive cells); and 3 (>30% positive cells). K5 expression was observed in all squamocellular carcinomas included in the present study with scores between 1 and 3. For well- and moderately-differentiated histopathological types, a maximum score of 3 was recorded for all of the cases, not including the laryngeal area, which presented a score of 2. The following scores were identified in the regions of the poorly differentiated carcinomas: Jaw, 3; gingival sulcus, 2; and tongue and submandibular area, 1. These observations may aid with an improved stratification of head and neck squamocellular carcinoma, thus improving the diagnosis and treatment strategies for this type of cancer.

No MeSH data available.


Related in: MedlinePlus