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Primary malignant melanoma of the cervix: A case report.

Liu Z, Wang H, Zhang X, Xu Q - Oncol Lett (2014)

Bottom Line: Chest X-ray and abdominopelvic computed tomography results were normal.Following combined radical surgery and chemotherapy, complete remission of the tumor was achieved.The patient has since been well for 30 months without recurrence subsequent to the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, P.R. China.

ABSTRACT
Primary malignant melanoma (MM) of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis. In the present study, the case of a 65-year-old female patient with an MM of the uterine cervix is reported. Diagnosis was confirmed by immunohistochemical methods using human melanoma black 45 antibody and S-100 protein. The tumor was identified as stage IB1 using the International Federation of Gynecology and Obstetrics classification. Chest X-ray and abdominopelvic computed tomography results were normal. The patient subsequently underwent a radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Following combined radical surgery and chemotherapy, complete remission of the tumor was achieved. The patient has since been well for 30 months without recurrence subsequent to the surgery.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical image of human melanoma black 45 expression in the cervical malignant melanoma specimen. Magnification, ×400.
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f3-ol-08-06-2661: Immunohistochemical image of human melanoma black 45 expression in the cervical malignant melanoma specimen. Magnification, ×400.

Mentions: The patient then underwent radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. A specimen of the uterus, cervix and vaginal cuff with bilateral attached adnexae, and a pelvic lymph node dissection specimen were received for analysis. Gross examination revealed a 4×2.5-cm2 ulcero-proliferative lesion in the cervix. The microscopic features of the specimen were comparable with those observed in the pre-operative biopsy (Fig. 1). The final diagnosis for the patient was International Federation of Gynecology and Obstetrics stage IB1 melanoma of the cervix with no lymph node metastasis. Immunohistochemistry revealed diffuse positive reactions for S-100 protein (Fig. 2), human melanoma black 45 (HMB-45; Fig. 3) and melanoma antigen recognized by T-cells (Fig. 4), which confirmed the diagnosis of MM, with no reaction for epithelial markers, namely high molecular weight-cytokeratin and epithelial membrane antigen.


Primary malignant melanoma of the cervix: A case report.

Liu Z, Wang H, Zhang X, Xu Q - Oncol Lett (2014)

Immunohistochemical image of human melanoma black 45 expression in the cervical malignant melanoma specimen. Magnification, ×400.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4214419&req=5

f3-ol-08-06-2661: Immunohistochemical image of human melanoma black 45 expression in the cervical malignant melanoma specimen. Magnification, ×400.
Mentions: The patient then underwent radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. A specimen of the uterus, cervix and vaginal cuff with bilateral attached adnexae, and a pelvic lymph node dissection specimen were received for analysis. Gross examination revealed a 4×2.5-cm2 ulcero-proliferative lesion in the cervix. The microscopic features of the specimen were comparable with those observed in the pre-operative biopsy (Fig. 1). The final diagnosis for the patient was International Federation of Gynecology and Obstetrics stage IB1 melanoma of the cervix with no lymph node metastasis. Immunohistochemistry revealed diffuse positive reactions for S-100 protein (Fig. 2), human melanoma black 45 (HMB-45; Fig. 3) and melanoma antigen recognized by T-cells (Fig. 4), which confirmed the diagnosis of MM, with no reaction for epithelial markers, namely high molecular weight-cytokeratin and epithelial membrane antigen.

Bottom Line: Chest X-ray and abdominopelvic computed tomography results were normal.Following combined radical surgery and chemotherapy, complete remission of the tumor was achieved.The patient has since been well for 30 months without recurrence subsequent to the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, P.R. China.

ABSTRACT
Primary malignant melanoma (MM) of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis. In the present study, the case of a 65-year-old female patient with an MM of the uterine cervix is reported. Diagnosis was confirmed by immunohistochemical methods using human melanoma black 45 antibody and S-100 protein. The tumor was identified as stage IB1 using the International Federation of Gynecology and Obstetrics classification. Chest X-ray and abdominopelvic computed tomography results were normal. The patient subsequently underwent a radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Following combined radical surgery and chemotherapy, complete remission of the tumor was achieved. The patient has since been well for 30 months without recurrence subsequent to the surgery.

No MeSH data available.


Related in: MedlinePlus