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Hepatitis E virus infections in blood donors, France.

Gallian P, Lhomme S, Piquet Y, Sauné K, Abravanel F, Assal A, Tiberghien P, Izopet J - Emerging Infect. Dis. (2014)

Bottom Line: We screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from France that had been processed with solvent-detergent for hepatitis E virus RNA.The detection rate was 1 HEV-positive sample/2,218 blood donations.Most samples (22/24) from viremic donors were negative for IgG and IgM against HEV.

View Article: PubMed Central - PubMed

ABSTRACT
We screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from France that had been processed with solvent-detergent for hepatitis E virus RNA. The detection rate was 1 HEV-positive sample/2,218 blood donations. Most samples (22/24) from viremic donors were negative for IgG and IgM against HEV.

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Frequency of blood donations positive for hepatitis E virus (HEV) RNA, by location and donor age and sex, France, November 27, 2012–December 1, 2013. Comparisons between groups by using χ2 and Fisher exact tests showed no significant differences.
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Figure 2: Frequency of blood donations positive for hepatitis E virus (HEV) RNA, by location and donor age and sex, France, November 27, 2012–December 1, 2013. Comparisons between groups by using χ2 and Fisher exact tests showed no significant differences.

Mentions: The geographic distribution of HEV-positive samples included all but 2 blood transfusion establishments (in Centre Atlantique and Ile de France) (Figure 1). The frequency of HEV RNA–positive samples was 0.072% (95% CI 0.067%–0.077%) in 3 blood transfusion establishments in southern France and 0.037% (95% CI 0.035%–0.037%,) in establishments in northern France (odds ratio [OR] 1.98, 95% CI 0.86–4.53, p = 0.14) (Figure 2). The frequency of HEV RNA–positive samples was 0.049% (95% CI 0.047%–0.051%) in men and 0.018% (95% CI 0.014%–0.022%) in women (OR 2.7, 95% CI 0.4–111.1, p = 0.51). The frequency of HEV RNA–positive samples was 0.048% (95% CI 0.046%–0.052%) for persons ≥45 years of age and 0.041% (95% CI 0.040%–0.042%) for persons <45 years of age (OR 1.2, 95% CI 0.5–2.9, p = 0.83).


Hepatitis E virus infections in blood donors, France.

Gallian P, Lhomme S, Piquet Y, Sauné K, Abravanel F, Assal A, Tiberghien P, Izopet J - Emerging Infect. Dis. (2014)

Frequency of blood donations positive for hepatitis E virus (HEV) RNA, by location and donor age and sex, France, November 27, 2012–December 1, 2013. Comparisons between groups by using χ2 and Fisher exact tests showed no significant differences.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4214305&req=5

Figure 2: Frequency of blood donations positive for hepatitis E virus (HEV) RNA, by location and donor age and sex, France, November 27, 2012–December 1, 2013. Comparisons between groups by using χ2 and Fisher exact tests showed no significant differences.
Mentions: The geographic distribution of HEV-positive samples included all but 2 blood transfusion establishments (in Centre Atlantique and Ile de France) (Figure 1). The frequency of HEV RNA–positive samples was 0.072% (95% CI 0.067%–0.077%) in 3 blood transfusion establishments in southern France and 0.037% (95% CI 0.035%–0.037%,) in establishments in northern France (odds ratio [OR] 1.98, 95% CI 0.86–4.53, p = 0.14) (Figure 2). The frequency of HEV RNA–positive samples was 0.049% (95% CI 0.047%–0.051%) in men and 0.018% (95% CI 0.014%–0.022%) in women (OR 2.7, 95% CI 0.4–111.1, p = 0.51). The frequency of HEV RNA–positive samples was 0.048% (95% CI 0.046%–0.052%) for persons ≥45 years of age and 0.041% (95% CI 0.040%–0.042%) for persons <45 years of age (OR 1.2, 95% CI 0.5–2.9, p = 0.83).

Bottom Line: We screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from France that had been processed with solvent-detergent for hepatitis E virus RNA.The detection rate was 1 HEV-positive sample/2,218 blood donations.Most samples (22/24) from viremic donors were negative for IgG and IgM against HEV.

View Article: PubMed Central - PubMed

ABSTRACT
We screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from France that had been processed with solvent-detergent for hepatitis E virus RNA. The detection rate was 1 HEV-positive sample/2,218 blood donations. Most samples (22/24) from viremic donors were negative for IgG and IgM against HEV.

Show MeSH
Related in: MedlinePlus